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本文引用的文献

1
Anandamide acts via kisspeptin in the regulation of testicular activity of the frog, Pelophylax esculentus.花生四烯乙醇胺通过亲吻素调节食用蛙（欧洲林蛙）的睾丸活动。
Mol Cell Endocrinol. 2016 Jan 15;420:75-84. doi: 10.1016/j.mce.2015.11.011. Epub 2015 Nov 14.
2
Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells.小鼠睾丸间质细胞中 kisspeptin 表达的发育及内分泌调节
Endocrinology. 2015 Apr;156(4):1514-22. doi: 10.1210/en.2014-1606. Epub 2015 Jan 30.
3
Kisspeptin drives germ cell progression in the anuran amphibian Pelophylax esculentus: a study carried out in ex vivo testes.吻肽驱动食用蛙（Pelophylax esculentus）的生殖细胞发育：一项体外睾丸实验研究
Gen Comp Endocrinol. 2015 Jan 15;211:81-91. doi: 10.1016/j.ygcen.2014.11.008. Epub 2014 Nov 18.
4
Modulators of hypothalamic-pituitary-gonadal axis for the control of spermatogenesis and sperm quality in vertebrates.用于控制脊椎动物精子发生和精子质量的下丘脑-垂体-性腺轴调节剂。
Front Endocrinol (Lausanne). 2014 Aug 18;5:135. doi: 10.3389/fendo.2014.00135. eCollection 2014.
5
Intra-testicular signals regulate germ cell progression and production of qualitatively mature spermatozoa in vertebrates.睾丸内信号调节脊椎动物生殖细胞的发育进程以及高质量成熟精子的产生。
Front Endocrinol (Lausanne). 2014 May 8;5:69. doi: 10.3389/fendo.2014.00069. eCollection 2014.
6
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level.内源性大麻素参与雄性脊椎动物生殖：中枢和性腺水平的调节机制。
Front Endocrinol (Lausanne). 2014 Apr 15;5:54. doi: 10.3389/fendo.2014.00054. eCollection 2014.
7
Hypothalamus-pituitary axis: an obligatory target for endocannabinoids to inhibit steroidogenesis in frog testis.下丘脑-垂体轴：内源性大麻素抑制青蛙睾丸类固醇生成的一个必需靶点。
Gen Comp Endocrinol. 2014 Sep 1;205:88-93. doi: 10.1016/j.ygcen.2014.02.010. Epub 2014 Feb 22.
8
Updates in reproduction coming from the endocannabinoid system.来自内源性大麻素系统的生殖领域的最新进展。
Int J Endocrinol. 2014;2014:412354. doi: 10.1155/2014/412354. Epub 2014 Jan 16.
9
A role for endocannabinoids in acute stress-induced suppression of the hypothalamic-pituitary-gonadal axis in male rats.内源性大麻素在急性应激诱导的雄性大鼠下丘脑-垂体-性腺轴抑制中的作用。
Clin Exp Reprod Med. 2013 Dec;40(4):155-62. doi: 10.5653/cerm.2013.40.4.155. Epub 2013 Dec 31.
10
Estrogens and spermiogenesis: new insights from type 1 cannabinoid receptor knockout mice.雌激素与精子发生：来自1型大麻素受体基因敲除小鼠的新见解
Int J Endocrinol. 2013;2013:501350. doi: 10.1155/2013/501350. Epub 2013 Nov 12.

神经内分泌CB1活性对成年睾丸间质细胞的影响。

Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells.

作者信息

Cobellis Gilda, Meccariello Rosaria, Chianese Rosanna, Chioccarelli Teresa, Fasano Silvia, Pierantoni Riccardo

机构信息

Dipartimento di Medicina Sperimentale, Seconda Università di Napoli , Napoli , Italy.

Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope , Napoli , Italy.

出版信息

Front Endocrinol (Lausanne). 2016 Jun 3;7:47. doi: 10.3389/fendo.2016.00047. eCollection 2016.

DOI:10.3389/fendo.2016.00047
PMID:27375550
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4891325/
Abstract

Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. In this short review, we provide a summary of the insights concerning neuroendocrine CB1 activity in male reproduction focusing on adult Leydig cell ontogenesis and steroid biosynthesis.

摘要

内源性大麻素通过大麻素受体在中枢和局部水平调控雄性生殖。大麻素受体CB1已在睾丸、哺乳动物和非哺乳动物动物模型的体细胞及生殖细胞中得到表征，其活性与睾丸间质细胞分化、类固醇生成、精子发生、精子质量及成熟相关。在这篇简短的综述中，我们总结了关于雄性生殖中神经内分泌CB1活性的见解，重点关注成年睾丸间质细胞的发生及类固醇生物合成。