Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Department of Movement Sciences and Wellbeing, Parthenope University of Naples, 80133 Naples, Italy.
Int J Mol Sci. 2021 Jan 19;22(2):972. doi: 10.3390/ijms22020972.
The endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hormones, regulate growth, differentiation, and many other functions in a broad range of target tissues and both sexes through the activation of nuclear and membrane estrogen receptors (ERs), which leads to genomic and non-genomic cell responses. Since ECS function overlaps or integrates with many other cell signaling systems, this review aims at updating the knowledge about the possible crosstalk between ECS and estrogen system (ES) at both central and peripheral level, with focuses on the central nervous system, reproduction, and cancer.
内源性大麻素系统（ECS）是一个脂质细胞信号系统，参与大脑和外周组织的生理和动态平衡。突触可塑性、神经内分泌功能、生殖和免疫反应等都需要功能性 ECS 的活动，而 ECS 功能障碍则会导致疾病的发生。雌激素，经典地被认为是女性类固醇激素，通过激活核和膜雌激素受体（ERs），在广泛的靶组织和两性中调节生长、分化和许多其他功能，从而导致基因组和非基因组细胞反应。由于 ECS 功能与许多其他细胞信号系统重叠或整合，因此本综述旨在更新关于 ECS 和雌激素系统（ES）在中枢和外周水平上可能的相互作用的知识，重点关注中枢神经系统、生殖和癌症。
