Durian Guido, Rahikainen Moona, Alegre Sara, Brosché Mikael, Kangasjärvi Saijaliisa
Department of Biochemistry, Molecular Plant Biology, University of Turku Turku, Finland.
Front Plant Sci. 2016 Jun 10;7:812. doi: 10.3389/fpls.2016.00812. eCollection 2016.
Biotic stress factors pose a major threat to plant health and can significantly deteriorate plant productivity by impairing the physiological functions of the plant. To combat the wide range of pathogens and insect herbivores, plants deploy converging signaling pathways, where counteracting activities of protein kinases and phosphatases form a basic mechanism for determining appropriate defensive measures. Recent studies have identified Protein Phosphatase 2A (PP2A) as a crucial component that controls pathogenesis responses in various plant species. Genetic, proteomic and metabolomic approaches have underscored the versatile nature of PP2A, which contributes to the regulation of receptor signaling, organellar signaling, gene expression, metabolic pathways, and cell death, all of which essentially impact plant immunity. Associated with this, various PP2A subunits mediate post-translational regulation of metabolic enzymes and signaling components. Here we provide an overview of protein kinase/phosphatase functions in plant immunity signaling, and position the multifaceted functions of PP2A in the tightly inter-connected regulatory network that controls the perception, signaling and responding to biotic stress agents in plants.
生物胁迫因素对植物健康构成重大威胁，可通过损害植物的生理功能显著降低植物生产力。为了对抗各种各样的病原体和食草昆虫，植物部署了趋同的信号通路，其中蛋白激酶和磷酸酶的拮抗活性构成了确定适当防御措施的基本机制。最近的研究已确定蛋白磷酸酶2A（PP2A）是控制各种植物物种发病机制反应的关键成分。遗传学、蛋白质组学和代谢组学方法强调了PP2A的多功能性质，它有助于调节受体信号传导、细胞器信号传导、基因表达、代谢途径和细胞死亡，所有这些都对植物免疫产生重要影响。与此相关的是，各种PP2A亚基介导代谢酶和信号成分的翻译后调控。在这里，我们概述了蛋白激酶/磷酸酶在植物免疫信号传导中的功能，并将PP2A的多方面功能定位在紧密相连的调控网络中，该网络控制着植物对生物胁迫因子的感知、信号传导和反应。
