Qin Lu, Li Yan, Jiao Yifeng, Fu Danqing, Ye Li, Ji Jinjun, Xie Guanqun, Fan Yongsheng, Xu Li
College of Basic Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
Evid Based Complement Alternat Med. 2016;2016:7219257. doi: 10.1155/2016/7219257. Epub 2016 Jun 8.
"Superior heat" is a popularization expression in TCM heat syndrome and has no counterpart in the modern medical system concept. Oral ulcer is considered to be a kind of clinical manifestation of "superior heat." Aphtha is a common and frequently occurring disease, which can be divided into excess heat and Yin deficiency. The aphtha of excess heat manifests the syndromes of acute occurrence, severe local symptoms, obvious swelling and pain, red tongue, yellow coating, and fast-powerful pulse. In this study, we found that there was an abnormal immune regulation in aphtha patients induced by excess heat. There are changes in the blood components, including abnormal serum protein expression (IL-4, MMP-19, MMP-9, and Activin A) and a higher percentage of CD4(+)CD25(+)Treg cells in the peripheral blood lymphocytes of the EXP group. Changes in the blood environment may be an important factor in the occurrence of aphtha caused by excess heat.
“上火”是中医热证中的一个通俗表述，在现代医学体系概念中并无对应。口腔溃疡被认为是“上火”的一种临床表现。口疮是一种常见且多发的疾病，可分为实热和阴虚两类。实热型口疮表现为发病急、局部症状重、肿痛明显、舌红、苔黄、脉数有力等症状。在本研究中，我们发现实热型口疮患者存在免疫调节异常。血液成分发生改变，包括血清蛋白表达异常（白细胞介素 -4、基质金属蛋白酶 -19、基质金属蛋白酶 -9 和激活素 A），且实验组外周血淋巴细胞中 CD4(+)CD25(+)调节性 T 细胞百分比更高。血液环境的改变可能是实热型口疮发病的一个重要因素。
