College of Traditional Chinese Medicine, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230000, China.
Department of Surgery, Cancer Hospital Affiliated to the University of Chinese Academy of Sciences, Hangzhou 310022, China.
J Tradit Chin Med. 2023 Apr;43(2):365-373. doi: 10.19852/j.cnki.jtcm.20221206.003.
To explore the correlation between tongue and oral microbiota, we studied the microbial community structure of different tongue coating types in patients with chronic gastritis.
16S rDNA gene sequencing and bioinformatics analysis were used to study the dynamic changes and correlation of microbial flora in patients with chronic gastritis, healthy people, and patients with different tongue fur. In addition, it was also discussed between the severity of gastritis and the microflora of tongue fur.
The microbial diversity of tongue fur in patients with chronic gastritis was significantly different from healthy controls. There were significant changes in bacterial communities' diversity and relative abundance between extra tongue fur in patients but not in healthy people. Oral bacteria with relative abundance > 1% and < 0.05 among different tongue fur flora were dominant bacteria, including 12 phyla such as and , and 256 genera such as and .
The changes in oral flora in patients with chronic gastritis were related to tongue fur. Therefore, the significant microbiota might enlighten further study on the correlation between tongue inspection and oral microbiota in patients with chronic gastritis.
探讨舌象与口腔微生物群的相关性，我们研究了慢性胃病患者不同舌苔类型的微生物群落结构。
采用 16S rDNA 基因测序和生物信息学分析方法，研究慢性胃病患者、健康人群和不同舌苔患者口腔微生物菌群的动态变化及相关性，并探讨了胃炎严重程度与舌苔菌群之间的关系。
慢性胃病患者舌苔的微生物多样性与健康对照组有显著差异。与健康人群相比，慢性胃病患者舌苔中细菌群落的多样性和相对丰度有明显变化。在不同舌苔菌群中，相对丰度>1%且<0.05 的口腔细菌为优势菌，包括 12 个门，如和 ，以及 256 个属，如和 。
慢性胃病患者口腔菌群的变化与舌苔有关。因此，这些显著的微生物群可能为进一步研究慢性胃病患者舌诊与口腔微生物群的相关性提供启示。
