主动脉瘤：病因发病机制与临床病理相关性
Aortic Aneurysm: Etiopathogenesis and Clinicopathologic Correlations.
作者信息
Ikeda Yoshihiko
机构信息
Department of Pathology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
出版信息
Ann Vasc Dis. 2016;9(2):73-9. doi: 10.3400/avd.ra.16-00018. Epub 2016 Apr 7.
Abstract
Aortic aneurysm (AA) is one of the life-threatening aortic diseases, leading to aortic rupture of any cause including atherosclerotic and non-atherosclerotic diseases. AA is diagnosed in a variable proportion of patients with dilated aorta by imaging modality. The etiopathogenesis of AA remains unclear in many aortic diseases. Furthermore, although it may be difficult to explain all phenotypes of patients even if genetic mutation could be identified in some proteins such as smooth muscle cell α-actin (ACTA2), myosin heavy chain 11 (MYH11) or SMAD3, individualized consideration of these factors in each patient is essential on the basis of clinicopathological characteristics.
摘要
主动脉瘤（AA）是一种危及生命的主动脉疾病，可导致因任何原因引起的主动脉破裂，包括动脉粥样硬化性和非动脉粥样硬化性疾病。通过影像学检查，在不同比例的主动脉扩张患者中可诊断出AA。在许多主动脉疾病中，AA的病因发病机制仍不清楚。此外，尽管即使在某些蛋白质如平滑肌细胞α-肌动蛋白（ACTA2）、肌球蛋白重链11（MYH11）或SMAD3中发现基因突变，也可能难以解释所有患者的表型，但根据临床病理特征对每个患者的这些因素进行个体化考虑至关重要。
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