Department of Rheumatology and Immunology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Sci Rep. 2019 Oct 1;9(1):14083. doi: 10.1038/s41598-019-50527-z.
Low-density lipoprotein cholesterol (LDL-C) has been associated with the occurrence of abdominal aortic aneurysm. However, whether LDL-C elevation associated with aneurysms in large vessel vasculitis is unknown. The aim of this study is to investigate the clinical and laboratory features of Takayasu arteritis (TAK) and explore the risk factors that associated with aneurysm in these patients. This retrospective study compared the clinical manifestations, laboratory parameters, and imaging results of 103 TAK patients with or without aneurysms and analyzed the risk factors of aneurysm formation. 20.4% of TAK patients were found to have aneurysms. The LDL-C levels was higher in the aneurysm group than in the non-aneurysm group (2.9 ± 0.9 mmol/l vs. 2.4 ± 0.9 mmol/l, p = 0.032). Elevated serum LDL-C levels increased the risk of aneurysm by 5.8-fold (p = 0.021, odds ratio [OR] = 5.767, 95% confidence interval [CI]: 1.302-25.543), and the cutoff value of level of serum LDL-C was 3.08 mmol/l. The risk of aneurysm was 4.2-fold higher in patients with disease duration >5 years (p = 0.042, OR = 4.237, 95% CI: 1.055-17.023), and 2.9-fold higher when an elevated erythrocyte sedimentation rate was present (p = 0.077, OR = 2.851, 95% CI: 0.891-9.115). In this study, elevated LDL-C levels increased the risk of developing aneurysms in patients with TAK.
低密度脂蛋白胆固醇（LDL-C）与腹主动脉瘤的发生有关。然而，尚不清楚大血管血管炎中 LDL-C 升高是否与动脉瘤有关。本研究旨在探讨大动脉炎（TAK）的临床和实验室特征，并探讨与这些患者动脉瘤相关的危险因素。本回顾性研究比较了 103 例 TAK 患者伴或不伴动脉瘤的临床表现、实验室参数和影像学结果，并分析了动脉瘤形成的危险因素。20.4%的 TAK 患者发现有动脉瘤。与无动脉瘤组相比，动脉瘤组的 LDL-C 水平更高（2.9±0.9mmol/L 比 2.4±0.9mmol/L，p=0.032）。血清 LDL-C 水平升高使动脉瘤的风险增加 5.8 倍（p=0.021，优势比[OR]＝5.767，95%置信区间[CI]：1.302-25.543），血清 LDL-C 水平的临界值为 3.08mmol/L。病程>5 年的患者发生动脉瘤的风险增加 4.2 倍（p=0.042，OR＝4.237，95%CI：1.055-17.023），红细胞沉降率升高的患者发生动脉瘤的风险增加 2.9 倍（p=0.077，OR＝2.851，95%CI：0.891-9.115）。在本研究中，升高的 LDL-C 水平增加了 TAK 患者发生动脉瘤的风险。
