Li Hao, Anuwongcharoen Nuttapat, Malik Aijaz Ahmad, Prachayasittikul Virapong, Wikberg Jarl E S, Nantasenamat Chanin
Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.
Int J Mol Sci. 2016 Jun 30;17(7):1023. doi: 10.3390/ijms17071023.
Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of d-amino acids (d-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of d-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists. Given the impact that d-AA incorporation has on HDPs, this review aims to fill that void with a systematic discussion of the impact of d-AA on HDPs.
宿主防御肽（HDPs）是先天免疫系统中带正电荷的两亲性成分，已显示出成为下一代有效对抗多种病原体和肿瘤的广谱治疗剂的巨大潜力。因此，人们采取了许多方法来提高HDPs的治疗效果。在这些方法中，引入d-氨基酸（d-AA）是一种在改善HDPs方面已取得持续成功的方法。尽管几乎所有HDP综述文章都简要提及了d-AA的作用，但令人惊讶的是，目前尚无专门针对该主题的系统综述。鉴于引入d-AA对HDPs的影响，本综述旨在通过对d-AA对HDPs影响的系统讨论来填补这一空白。
