Chen Risheng, Yang Mingxiu, Huang Weiguo, Wang Baiyun
Department of Anesthesiology, Affiliated Nanhua Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology (2016TP1015), Cancer Research Institute, Hengyang Medical College of University of South China, Hengyang, Hunan 421001, P.R. China.
Exp Ther Med. 2021 Jul;22(1):769. doi: 10.3892/etm.2021.10201. Epub 2021 May 17.
Gastric cancer is a common digestive tract malignancy that is mainly treated with surgery combined with perioperative adjuvant chemoradiotherapy and biological targeted therapy. However, the diagnosis rate of early gastric cancer is low and both postoperative recurrence and distant metastasis are thorny problems. Therefore, it is essential to study the pathogenesis of gastric cancer and search for more effective means of treatment. The nuclear factor-κB (NF-κB) signaling pathway has an important role in the occurrence and development of gastric cancer and recent studies have revealed that microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are able to regulate this pathway through a variety of mechanisms. Understanding these interrelated molecular mechanisms is helpful in guiding improvements in gastric cancer treatment. In the present review, the functional associations between miRNAs, lncRNAs and the NF-κB signaling pathway in the occurrence, development and prognosis of gastric cancer were discussed. It was concluded that miRNAs and lncRNAs have complex relations with the NF-κB signaling pathway in gastric cancer. miRNAs/target genes/NF-κB/target proteins, signaling molecules/NF-κB/miRNAs/target genes, lncRNAs/miRNAs/NF-κB/genes or mRNAs, lncRNAs/target genes/NF-Κb/target proteins, and lncRNAs/NF-κB/target proteins cascades are all important factors in the occurrence and development of gastric cancer.
胃癌是一种常见的消化道恶性肿瘤，主要通过手术联合围手术期辅助放化疗及生物靶向治疗。然而，早期胃癌的诊断率较低，术后复发和远处转移都是棘手的问题。因此，研究胃癌的发病机制并寻找更有效的治疗手段至关重要。核因子-κB（NF-κB）信号通路在胃癌的发生发展中起重要作用，最近的研究表明，微小RNA（miRNA）和长链非编码RNA（lncRNA）能够通过多种机制调节该通路。了解这些相互关联的分子机制有助于指导胃癌治疗的改进。在本综述中，讨论了miRNA、lncRNA与NF-κB信号通路在胃癌发生、发展及预后中的功能关联。得出的结论是，miRNA和lncRNA在胃癌中与NF-κB信号通路存在复杂关系。miRNA/靶基因/NF-κB/靶蛋白、信号分子/NF-κB/miRNA/靶基因、lncRNA/miRNA/NF-κB/基因或mRNA、lncRNA/靶基因/NF-κB/靶蛋白以及lncRNA/NF-κB/靶蛋白级联反应都是胃癌发生发展的重要因素。
