Minocha Y C, Sood V K, Chopra R, Khurana S, Ram S
Indian J Med Res. 1989 Mar;89:92-4.
In vitro sensitivity tests indicated econazole to be the best drug against all 30 isolates of Trichophyton species followed by miconazole, clotrimazole and tolnaftate. Econazole inhibited the growth of all isolates of Trichophyton species in low concentrations of 2-4 micrograms/ml except one isolate of T. rubrum which was inhibited by a concentration of 8 micrograms/ml. Miconazole was also able to inhibit growth of 73.3 per cent isolates of Trichophyton species in low concentrations of 2-4 micrograms/ml. On the other hand, only 13.3 per cent isolates were found sensitive at 2-4 micrograms/ml concentration to tolnaftate and clotrimazole. Relative resistance was encountered by 7 isolates (23.3%) to tolnaftate and 2 isolates (6.6%) to clotrimazole. Isolates of T. tonsurans were resistant to tolnaftate, whereas, the isolate of T. mentagrophytes was sensitive to all the drugs in low concentrations.
体外敏感性试验表明，益康唑是针对所有30株毛癣菌属菌株的最佳药物，其次是咪康唑、克霉唑和托萘酯。益康唑在2 - 4微克/毫升的低浓度下就能抑制所有毛癣菌属菌株的生长，但有一株红色毛癣菌菌株需在8微克/毫升的浓度下才能被抑制。咪康唑在2 - 4微克/毫升的低浓度下也能抑制73.3%的毛癣菌属菌株生长。另一方面，在2 - 4微克/毫升浓度下，仅13.3%的菌株对托萘酯和克霉唑敏感。有7株菌株（23.3%）对托萘酯产生相对耐药，2株菌株（6.6%）对克霉唑产生相对耐药。断发毛癣菌菌株对托萘酯耐药，而须癣毛癣菌菌株在低浓度下对所有药物均敏感。
