Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Canada.
Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.
Sci Total Environ. 2016 Nov 1;569-570:1022-1031. doi: 10.1016/j.scitotenv.2016.06.134. Epub 2016 Jul 2.
Endocrine-related adverse health effects from exposure to heavy metals such as lead, arsenic, cadmium, and mercury are yet to be adequately described. The purpose of this review was to gain insight into maternal exposure to heavy metals, and to identify potential endocrine-related adverse health effects in the mother and the infant.
Relevant databases were searched for original research reports and a total of 46 articles were retained for scrutiny. Required data was extracted from these studies and their methodology was assessed.
Impaired fetal growth was observed from exposure to all endocrine disrupting metals, while exposure to lead and arsenic were associated with spontaneous abortion, stillbirth and neonatal deaths. Maternal exposure to arsenic was associated with impaired glucose tolerance in these mothers.
Impaired fetal growth, fetal loss, and neonatal deaths were significantly associated with heavy metals exposure during pregnancy; however, hypertension and gestational diabetes require further investigation.
重金属（如铅、砷、镉和汞）暴露对健康的内分泌相关不良影响尚未得到充分描述。本综述的目的是深入了解母亲暴露于重金属的情况，并确定母亲和婴儿潜在的与内分泌相关的不良健康影响。
检索了相关数据库中的原始研究报告，共保留了 46 篇文章进行审查。从这些研究中提取了所需数据，并评估了其方法学。
所有内分泌干扰金属的暴露均观察到胎儿生长受损，而铅和砷的暴露与自然流产、死产和新生儿死亡有关。母亲暴露于砷与这些母亲的葡萄糖耐量受损有关。
怀孕期间重金属暴露与胎儿生长受损、胎儿丢失和新生儿死亡显著相关；然而，高血压和妊娠期糖尿病需要进一步研究。
