Goodrich Jaclyn M, Ingle Mary E, Domino Steven E, Treadwell Marjorie C, Dolinoy Dana C, Burant Charles, Meeker John D, Padmanabhan Vasantha
Department of Environmental Health Sciences,University of Michigan School of Public Health,Ann Arbor, MI,USA.
Department of Obstetrics and Gynecology,University of Michigan,Ann Arbor, MI,USA.
J Dev Orig Health Dis. 2019 Aug;10(4):447-458. doi: 10.1017/S204017441800106X. Epub 2019 Jan 30.
Exposures to endocrine disrupting chemicals and metals are near ubiquitous worldwide, and their potential impact on children is a major public health concern. This pilot study was designed to characterize exposures to phthalates, phenols and metals among pregnant women in the first trimester, and to examine associations with fetal biometrics and birth weight. A total of 41 chemicals and elements were analyzed in urine from 56 mothers with full-term newborns from the Michigan Mother-Infant Pairs study. Bivariate analyses identified predictors of exposure biomarkers. Associations between birth weight, Fenton z-scores and second trimester fetal biometrics with toxicants were examined via multivariable linear regression. An average of 30 toxicants were detected in maternal urine. Fast food consumption was associated with several phthalate metabolites, phenols and metals, and canned food consumption with bisphenol F (P <0.05). Mono (3-carboxypropyl) phthalate was significantly associated with higher birth weight and Fenton z-score while the opposite was observed for bisphenol S. Estimated femur length from ultrasonography was significantly inversely associated with arsenic, barium and lead. While limited by sample size, this study is one of the first to evaluate birth outcomes with respect to emerging endocrine disrupting chemicals and to examine associations between toxicants and fetal biometrics. Exposure assessment was provided by the National Institute of Environmental Health Sciences' Children's Health Exposure Analysis Resource (NIEHS CHEAR), a resource available to children's studies with the goal of combining data across cohorts in an effort to characterize the impact of toxicants on child health from birth and beyond.
在全球范围内，接触内分泌干扰化学物质和金属的情况几乎无处不在，它们对儿童的潜在影响是一个重大的公共卫生问题。这项初步研究旨在描述孕早期孕妇邻苯二甲酸盐、酚类和金属的接触情况，并研究其与胎儿生物特征和出生体重之间的关联。在密歇根母婴配对研究中，对56名足月新生儿母亲的尿液进行了分析，共检测了41种化学物质和元素。双变量分析确定了接触生物标志物的预测因素。通过多变量线性回归研究了出生体重、芬顿z评分和孕中期胎儿生物特征与有毒物质之间的关联。在孕妇尿液中平均检测到30种有毒物质。快餐消费与几种邻苯二甲酸酯代谢物、酚类和金属有关，罐装食品消费与双酚F有关（P<0.05）。单（3-羧丙基）邻苯二甲酸酯与较高的出生体重和芬顿z评分显著相关，而双酚S则相反。超声估计的股骨长度与砷、钡和铅显著负相关。尽管受样本量限制，但本研究是首批评估新兴内分泌干扰化学物质对出生结局影响以及研究有毒物质与胎儿生物特征之间关联的研究之一。暴露评估由美国国家环境健康科学研究所的儿童健康暴露分析资源（NIEHS CHEAR）提供，该资源可供儿童研究使用，目的是整合不同队列的数据，以描述有毒物质从出生及以后对儿童健康的影响。
