肥胖患者循环中的SIRT1与心外膜脂肪厚度呈负相关。

Circulating SIRT1 inversely correlates with epicardial fat thickness in patients with obesity.

作者信息

Mariani S, Costantini D, Lubrano C, Basciani S, Caldaroni C, Barbaro G, Poggiogalle E, Donini L M, Lenzi A, Gnessi L

机构信息

Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, "Sapienza" University of Rome, 00161 Rome, Italy.

出版信息

Nutr Metab Cardiovasc Dis. 2016 Nov;26(11):1033-1038. doi: 10.1016/j.numecd.2016.06.001. Epub 2016 Jun 16.

DOI:10.1016/j.numecd.2016.06.001

PMID:27378396

Abstract

BACKGROUND AND AIM

Obesity is increasing worldwide and is related to undesirable cardiovascular outcomes. Epicardial fat (EF), the heart visceral fat depot, increases with obesity and correlates with cardiovascular risk. SIRT1, an enzyme regulating metabolic circuits linked with obesity, has a cardioprotective effect and is a predictor of cardiovascular events. We aimed to assess the relationship of EF thickness (EFT) with circulating SIRT1 in patients with obesity.

METHODS AND RESULTS

Sixty-two patients affected by obesity and 23 lean controls were studied. Plasma SIRT1 concentration was determined by enzyme-linked immunosorbent assay (ELISA). EFT was measured by echocardiography. Body mass index (BMI), waist circumference, heart rate (HR), blood pressure, and laboratory findings (fasting glucose, insulin, HbA1c, cholesterol, and triglycerides) were assessed. SIRT1 was significantly lower (P = 0.002) and EFT was higher (P < 0.0001) in patients with obesity compared with lean controls. SIRT1 showed a negative correlation with EFT and HR in the obesity group (ρ = -0.350, P = 0.005; ρ = -0.303, P = 0.008, respectively). After adjustment for obesity-correlated variables, multiple linear regression analysis showed that EFT remained the best correlate of SIRT1 (β = -0.352, P = 0.016).

CONCLUSIONS

Circulating SIRT1 correlates with the visceral fat content of the heart. Serum SIRT1 levels might provide additional information for risk assessment of coronary artery disease in patients with obesity.

摘要

背景与目的

肥胖在全球范围内呈上升趋势，且与不良心血管结局相关。心外膜脂肪（EF）作为心脏内脏脂肪储存库，随肥胖增加而增多，并与心血管风险相关。沉默调节蛋白1（SIRT1）是一种调节与肥胖相关代谢途径的酶，具有心脏保护作用，是心血管事件的预测指标。我们旨在评估肥胖患者的心外膜脂肪厚度（EFT）与循环SIRT1之间的关系。

方法与结果

对62例肥胖患者和23例瘦对照者进行研究。采用酶联免疫吸附测定（ELISA）法测定血浆SIRT1浓度。通过超声心动图测量EFT。评估体重指数（BMI）、腰围、心率（HR）、血压及实验室检查结果（空腹血糖、胰岛素、糖化血红蛋白、胆固醇和甘油三酯）。与瘦对照者相比，肥胖患者的SIRT1显著降低（P = 0.002），EFT更高（P < 0.0001）。在肥胖组中，SIRT1与EFT及HR呈负相关（分别为ρ = -0.350，P = 0.005；ρ = -0.303，P = 0.008）。在对与肥胖相关的变量进行校正后，多元线性回归分析显示EFT仍然是与SIRT1最相关的因素（β = -0.352，P = 0.016）。