Kim Dae Hyun, Rich Michael W
Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Division of Cardiology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.
Can J Cardiol. 2016 Sep;32(9):1097-107. doi: 10.1016/j.cjca.2016.04.003. Epub 2016 Apr 20.
Multimorbidity, defined as the presence of 2 or more chronic conditions, is common among older adults with cardiovascular disease. These individuals are at increased risk for poor health outcomes and account for a large proportion of health care utilization. Clinicians are challenged with the heterogeneity of this population, the complexity of the treatment regimen, limited high-quality evidence, and fragmented health care systems. Each treatment recommended by a clinical practice guideline for a single cardiovascular disease might be rational, but the combination of all evidence-based recommendations can be impractical or even harmful to individuals with multimorbidity. These challenges can be overcome with a patient-centred approach that incorporates the individual's preferences, relevant evidence, the overall and condition-specific prognosis, clinical feasibility of treatments, and interactions with other treatments and coexisting chronic conditions. The ultimate goal is to maximize benefits and minimize harms by optimizing adherence to the most essential treatments, while acknowledging trade-offs between treatments for different health conditions. It might be necessary to discontinue therapies that are not essential or potentially harmful to decrease the risk of drug-drug and drug-disease interactions from polypharmacy. A decision to initiate, withhold, or stop a treatment should be on the basis of the time horizon to benefits vs the individual's prognosis. In this review, we illustrate how cardiologists and general practitioners can adopt a patient-centred approach to focus on the aspects of cardiovascular and noncardiovascular health that have the greatest effect on functioning and quality of life in older adults with cardiovascular disease and multimorbidity.
多病共存,定义为存在两种或更多种慢性疾病,在患有心血管疾病的老年人中很常见。这些个体健康状况不佳的风险增加,并且在医疗保健利用中占很大比例。临床医生面临着这一人群的异质性、治疗方案的复杂性、高质量证据有限以及医疗保健系统碎片化等挑战。临床实践指南针对单一心血管疾病推荐的每种治疗可能都是合理的,但所有循证推荐的组合对于多病共存的个体可能不切实际甚至有害。通过以患者为中心的方法可以克服这些挑战,该方法纳入个体的偏好、相关证据、总体和特定疾病的预后、治疗的临床可行性以及与其他治疗和共存慢性病的相互作用。最终目标是通过优化对最基本治疗的依从性来最大化益处并最小化危害,同时认识到不同健康状况治疗之间的权衡。可能有必要停用非必要或有潜在危害的疗法,以降低多重用药导致的药物相互作用和药物与疾病相互作用的风险。启动、停用或停止一种治疗的决定应基于获益的时间范围与个体的预后。在本综述中,我们阐述了心脏病专家和全科医生如何采用以患者为中心的方法,关注对患有心血管疾病和多病共存的老年人的功能和生活质量影响最大的心血管和非心血管健康方面。