徐长卿根中的C21甾体苷类成分。
C21 steroidal glycosides from the roots of Cynanchum paniculatum.
作者信息
Zhao Dan, Feng Baomin, Chen Shaofei, Chen Gang, Li Zhifeng, Lu Xiaojie, Sang Xianan, An Xiao, Wang Haifeng, Pei Yuehu
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
School of Life Sciences and Biotechnology, Dalian University, Dalian 116622, China.
出版信息
Fitoterapia. 2016 Sep;113:51-7. doi: 10.1016/j.fitote.2016.07.001. Epub 2016 Jul 2.
As a part of our continuing research for bioactive constituents from Cynanchum plants, four new C21 steroidal glycosides, cynapanoside D-G (1-4), together with six known compounds (5-10) were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. Compound 8 exhibited potent inhibitory activities against HL-60, HT-29, PC-3 and MCF-7 cell lines with IC50 values of 8.3, 7.5, 34.3 and 19.4μM, respectively and compounds 1-4 and 9 displayed moderate cytotoxicity against the four cell lines. The in vitro antioxidant activities of compounds 1-4, 8 and 9 were assayed by DPPH radical scavenging activity. Antibacterial and antifungal activities of compounds 1-4, 8 and 9 were also tested.
作为我们对鹅绒藤属植物生物活性成分持续研究的一部分，从徐长卿（Cynanchum paniculatum (Bge.) Kitag.）的根部分离得到了4个新的C21甾体糖苷，鹅绒藤苷D-G（1-4），以及6个已知化合物（5-10）。通过一维和二维核磁共振光谱数据以及高分辨电喷雾电离质谱分析确定了它们的结构。化合物8对HL-60、HT-29、PC-3和MCF-7细胞系表现出强抑制活性，IC50值分别为8.3、7.5、34.3和19.4μM，化合物1-4和9对这4种细胞系显示出中等细胞毒性。通过DPPH自由基清除活性测定了化合物1-4、8和9的体外抗氧化活性。还测试了化合物1-4、8和9的抗菌和抗真菌活性。
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