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从徐长卿根部分离得到的两种新的C21甾体糖苷。

Two New C21 Steroidal Glycosides from the Roots of Cynanchum paniculatum.

作者信息

Yu Hai-Li, Long Qin, Yi Wen-Fang, Yang Bao-Jia, Song Yu, Ding Xiao, Li Shun-Lin, Hao Xiao-Jiang

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2019 Jun;9(3):209-214. doi: 10.1007/s13659-019-0205-2. Epub 2019 Apr 26.

DOI:10.1007/s13659-019-0205-2
PMID:31028545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6538742/
Abstract

Two new C21 steroidal glycosides, paniculatumosides H and I, together with four known ones were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were identified by spectroscopic methods including extensive 1D and 2D NMR techniques. All compounds were subjected to detect the anti-tobacco mosaic virus (TMV) activities and their cytotoxities against three human tumor cell lines (SMMC-7721, MDA-MB-231 and A549). The results showed that compounds 1 and 5 exhibited potent protective activities against TMV, while 2, 4 and 6 had moderate effects on the SMMC-7721 cancer cells viability.

摘要

从徐长卿（Cynanchum paniculatum (Bge.) Kitag.）的根部分离得到两个新的C21甾体苷类化合物，徐长卿苷H和I，以及四个已知化合物。通过包括广泛的一维和二维核磁共振技术在内的光谱方法鉴定了它们的结构。对所有化合物进行了抗烟草花叶病毒（TMV）活性及其对三种人类肿瘤细胞系（SMMC-7721、MDA-MB-231和A549）的细胞毒性检测。结果表明，化合物1和5对TMV表现出强效保护活性，而化合物2、4和6对SMMC-7721癌细胞活力有中等影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/d49cef88590f/13659_2019_205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/f1c126bf74d6/13659_2019_205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/ea53dbbfebe2/13659_2019_205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/0dda1f04e082/13659_2019_205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/f84e8a0b6b9d/13659_2019_205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/d49cef88590f/13659_2019_205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/f1c126bf74d6/13659_2019_205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/ea53dbbfebe2/13659_2019_205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/0dda1f04e082/13659_2019_205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/f84e8a0b6b9d/13659_2019_205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/550b/6538742/d49cef88590f/13659_2019_205_Fig5_HTML.jpg

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