Chung Heesung, Multhaupt Hinke A B, Oh Eok-Soo, Couchman John R
Department of Life Sciences and the Research Center for Cellular Homeostasis, Ewha Womans University, Seoul, Korea.
Department of Biomedical Sciences and Biotech Research & Innovation Center, University of Copenhagen, Denmark.
FEBS Lett. 2016 Aug;590(15):2408-17. doi: 10.1002/1873-3468.12280. Epub 2016 Jul 15.
Syndecans are transmembrane heparan sulfate proteoglycans, with roles in development, tumorigenesis and inflammation, and growing evidence for involvement in tissue regeneration. This is a fast developing field with the prospect of utilizing tissue engineering and biomaterials in novel therapies. Syndecan receptors are not only ubiquitous in mammalian tissues, regulating cell adhesion, migration, proliferation, and differentiation through independent signaling but also working alongside other receptors. Their importance is highlighted by an ability to interact with a diverse array of ligands, including extracellular matrix glycoproteins, growth factors, morphogens, and cytokines that are important regulators of regeneration. We also discuss the potential for syndecans to regulate stem cell properties, and suggest that understanding these proteoglycans is relevant to exploiting cell, tissue, and materials technologies.
Syndecans是跨膜硫酸乙酰肝素蛋白聚糖，在发育、肿瘤发生和炎症中发挥作用，并且越来越多的证据表明其参与组织再生。这是一个快速发展的领域，有望在新型疗法中利用组织工程和生物材料。Syndecan受体不仅在哺乳动物组织中普遍存在，通过独立信号传导调节细胞粘附、迁移、增殖和分化，还与其他受体协同作用。它们与多种配体相互作用的能力突出了其重要性，这些配体包括细胞外基质糖蛋白、生长因子、形态发生素和细胞因子，它们是再生的重要调节因子。我们还讨论了Syndecans调节干细胞特性的潜力，并表明了解这些蛋白聚糖与开发细胞、组织和材料技术相关。
