Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Obesity Research Group, Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
BMC Res Notes. 2024 Jun 15;17(1):164. doi: 10.1186/s13104-024-06822-8.
Bariatric surgery induces a significant loss of both fat mass (FM) and fat-free mass (FFM). The proteoglycan receptor syndecan-4 (SDC4) plays a crucial role in adipose tissue and skeletal muscle functions. Thus, this study was performed (i) to assess plasma SDC4 levels after both Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) surgeries, and (ii) to explore potential associations with changes in body composition variables.
Twenty-six patients (17 females) with severe obesity underwent SG (n = 13) or RYGB (n = 13) and were followed up to 1 year (1Y). Body weight, FM, FFM, and SCD4 were measured at baseline (BL), and at week 11 (W11) and 1Y after surgery. Independently of procedure, there was a significant body weight loss at W11, with an average FM and FFM reduction of 13.7 ± 0.6 kg and 5.3 ± 0.5 kg, respectively. Participants continued to lose weight afterwards, with a total weigth loss of 38.2 ± 1.5 kg at 1Y. No associations were found at BL between SDC4 levels and any anthropometric variable; however, SDC4 levels were lower than BL at both W11 and 1Y, independently of type of surgery. Additionally, changes in SDC4 between BL and 1Y were positively correlated with weight and FFM loss during the same period.
ClinicalTrials.gov NCT04051190 on 09/08/2019.
减重手术会导致体脂肪量（FM）和去脂体重（FFM）显著减少。蛋白聚糖受体 syndecan-4（SDC4）在脂肪组织和骨骼肌功能中起着至关重要的作用。因此，本研究（i）评估了袖状胃切除术（SG）和 Roux-en-Y 胃旁路术（RYGB）后血浆 SDC4 水平，（ii）探讨了其与身体成分变量变化的潜在关联。
26 名（17 名女性）严重肥胖患者接受了 SG（n=13）或 RYGB（n=13）手术，并随访 1 年（1Y）。在基线（BL）、第 11 周（W11）和手术后 1 年（1Y）测量体重、FM、FFM 和 SCD4。无论手术方式如何，W11 时体重均显著减轻，FM 和 FFM 分别平均减少 13.7±0.6kg 和 5.3±0.5kg。随后患者继续减重，1Y 时总减重 38.2±1.5kg。BL 时 SDC4 水平与任何人体测量变量之间均无相关性；然而，W11 和 1Y 时 SDC4 水平均低于 BL，与手术类型无关。此外，BL 和 1Y 之间 SDC4 的变化与同期体重和 FFM 的减少呈正相关。
ClinicalTrials.gov NCT04051190 于 2019 年 9 月 8 日注册。
