Suliman Sharain, Anthonissen Lise, Carr Jonathan, du Plessis Stefan, Emsley Robin, Hemmings Sian M J, Lochner Christine, McGregor Nathaniel, van den Heuvel Leigh, Seedat Soraya
From the Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Harv Rev Psychiatry. 2016 Jul-Aug;24(4):271-93. doi: 10.1097/HRP.0000000000000106.
Previous reports have suggested a high prevalence of overweight and obesity among individuals with posttraumatic stress disorder (PTSD). Few studies, however, systematically analyze the relationship between PTSD and body mass index (BMI). We conducted a systematic review and meta-analysis aimed at estimating the association between PTSD and BMI. Fifty-four articles were reviewed, 30 of which (with 191,948 individuals with PTSD and 418,690 trauma-exposed individuals or healthy controls) were eligible for inclusion in the meta-analysis. The pooled standard mean difference, based on a random-effects model, was 0.41 (95% confidence interval, 0.28-0.54; z = 6.26; p < .001). Statistical heterogeneity between the included studies was high (p < .001; I = 99%). Despite limitations, the findings of this systematic review and meta-analysis suggest an association between PTSD and BMI. Furthermore, longitudinal studies tentatively indicate that PTSD may lead to an increase in BMI and, as such, to the development of overweight/obesity, particularly in women. Further prospective studies and research elaborating the nature and etiology of the association are required.
先前的报告表明，创伤后应激障碍（PTSD）患者中超重和肥胖的患病率很高。然而，很少有研究系统地分析PTSD与体重指数（BMI）之间的关系。我们进行了一项系统评价和荟萃分析，旨在评估PTSD与BMI之间的关联。共检索了54篇文章，其中30篇（涉及191,948名PTSD患者以及418,690名暴露于创伤的个体或健康对照）符合纳入荟萃分析的标准。基于随机效应模型的合并标准平均差为0.41（95%置信区间为0.28 - 0.54；z = 6.26；p <.001）。纳入研究之间的统计异质性很高（p <.001；I² = 99%）。尽管存在局限性，但这项系统评价和荟萃分析的结果表明PTSD与BMI之间存在关联。此外，纵向研究初步表明，PTSD可能导致BMI升高，进而导致超重/肥胖的发生，尤其是在女性中。需要进一步开展前瞻性研究以及详细阐述这种关联的性质和病因的研究。
