Adler D, Maier H
Dept. of Otorhinolaryngology, University of Heidelberg, FRG.
J Clin Chem Clin Biochem. 1989 Apr;27(4):232-3.
The excretion of ciprofloxacin (Ciprobay) via the human parotid gland was investigated. 2 h after an intravenous bolus injection (200 mg ciprofloxacin) mean serum concentrations of 0.43 mg/l were achieved, and these decreased within 6 h after injection to 0.17 mg/l. The concentrations of the gyrase inhibitor in parotid saliva showed a close positive correlation to the serum levels (r = 0.96), but they were significantly lower than serum levels. They decreased from 0.1 mg/l 2 h after injection to 0.04 mg/l after 6 h.
研究了环丙沙星（拜复乐）通过人类腮腺的排泄情况。静脉推注（200毫克环丙沙星）2小时后，平均血清浓度达到0.43毫克/升，注射后6小时内降至0.17毫克/升。腮腺唾液中环丙沙星这种促旋酶抑制剂的浓度与血清水平呈密切正相关（r = 0.96），但明显低于血清水平。其浓度从注射后2小时的0.1毫克/升降至6小时后的0.04毫克/升。
