Rubin R H, Fischman A J, Needleman M, Wilkinson R, Callahan R J, Khaw B A, Hansen W P, Kramer P B, Strauss H W
Infectious Disease Unit of the Medical Service, Massachusetts General Hospital, Boston 02114.
J Nucl Med. 1989 Mar;30(3):385-9.
The accumulation of nonspecific polyclonal human immunoglobulin (IgG) radiolabeled with 125I or 111In was compared to that of [67Ga]citrate and [99mTc]albumin in rats with deep thigh inflammation due to Escherichia coli infection. Serial scintigrams were acquired at 1, 3, 24, and in some cases, 48 hr after injection. As early as 3 hr postinjection, [111In]IgG showed greater accumulation at the lesion than [99mTc]HSA (p less than 0.01). Both [125I]IgG and [111In]IgG showed greater accumulation than [67Ga]citrate (p less than 0.01). At 24 hr, IgG image definition increased, while HSA image definition decreased, and the intensity of accumulation of both IgG preparations was greater than that of [67Ga]citrate or [99mTc]HSA (p less than 0.01). At all imaging times, [67Ga]citrate accumulation was surprisingly low. In inflammation produced by Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, or turpentine, [111In]IgG accumulation was similar to the results obtained with Escherichia coli. These studies suggest that focal sites of inflammation can be detected with radiolabeled nonspecific human polyclonal IgG.
将用¹²⁵I或¹¹¹In放射性标记的非特异性多克隆人免疫球蛋白（IgG）的蓄积情况，与[⁶⁷Ga]柠檬酸盐和[⁹⁹ᵐTc]白蛋白在因大肠杆菌感染导致大腿深部炎症的大鼠体内的蓄积情况进行了比较。在注射后1、3、24小时，以及在某些情况下48小时采集系列闪烁扫描图像。注射后3小时，[¹¹¹In]IgG在病变部位的蓄积就比[⁹⁹ᵐTc]人血清白蛋白（HSA）更多（p＜0.01）。[¹²⁵I]IgG和[¹¹¹In]IgG的蓄积都比[⁶⁷Ga]柠檬酸盐更多（p＜0.01）。24小时时，IgG图像清晰度增加，而HSA图像清晰度降低，两种IgG制剂的蓄积强度都大于[⁶⁷Ga]柠檬酸盐或[⁹⁹ᵐTc]HSA（p＜0.01）。在所有成像时间点，[⁶⁷Ga]柠檬酸盐的蓄积都出奇地低。在由铜绿假单胞菌、金黄色葡萄球菌、肺炎克雷伯菌、白色念珠菌或松节油引起的炎症中，[¹¹¹In]IgG的蓄积情况与大肠杆菌感染时的结果相似。这些研究表明，放射性标记的非特异性人多克隆IgG能够检测出炎症病灶。
