a Department of Clinical and Experimental Medicine, University Hospital , Linkoping University , Linköping , Sweden.
Expert Rev Mol Diagn. 2016 Sep;16(9):933-940. doi: 10.1080/14737159.2016.1210513. Epub 2016 Jul 18.
In all forms of diabetes, especially so in Type 1 diabetes (T1D), beta cell function is crucial for the course. The interest for residual beta cell function has been meagre, but increased in recent years with interventions to preserve function. Areas covered: Importance and clinical use of C-peptide in Type 1 diabetes. Data for this review were identified by searches of PubMed, and references from relevant articles using the search terms: "type 1 diabetes", "C-peptide", "beta cell function", "HbA1c", quality of life", "complications". Abstracts and reports from meetings were not included. Expert commentary: C-peptide may help to get a correct diagnosis, and it is of practical clinical value to know degree of residual insulin secretion to diminish the risk of severe hypoglycaemia and ketoacidosis. Evidence shows that even a quite reduced beta cell function may play an important role for quality of life, for metabolic balance/control, possibility to avoid complications and even for long-term survival. Furthermore, the evidence is increasing for C-peptide being a hormone per se.
在所有类型的糖尿病中，尤其是 1 型糖尿病 (T1D)，β细胞功能对病程至关重要。人们对残余β细胞功能的兴趣一直不大，但近年来，随着保护β细胞功能的干预措施的增加，人们对β细胞功能的兴趣有所增加。涵盖领域：1 型糖尿病中 C 肽的重要性和临床应用。本综述的数据通过在 PubMed 上搜索以及使用以下搜索词在相关文章的参考文献中搜索确定：“type 1 diabetes”、“C-peptide”、“beta cell function”、“HbA1c”、“quality of life”、“complications”。会议摘要和报告未包括在内。专家评论：C 肽有助于正确诊断，了解残余胰岛素分泌程度可降低严重低血糖和酮症酸中毒的风险，具有实际的临床价值。有证据表明，即使β细胞功能明显降低，也可能对生活质量、代谢平衡/控制、避免并发症甚至长期生存产生重要影响。此外，越来越多的证据表明 C 肽本身就是一种激素。
