Cabral Maria, Araújo Joana, Teixeira Joana, Barros Henrique, Martins Sandra, Guimarães João Tiago, Lopes Carla, Ramos Elisabete
ISPUP-EPI Unit, Universidade do Porto, Rua das Taipas, nº 135, 4050-600 Porto, Portugal; Departamento de Epidemiologia Clínica, Medicina Preditiva e Saúde Pública, Faculdade de Medicina, Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200 - 319 Porto, Portugal.
ISPUP-EPI Unit, Universidade do Porto, Rua das Taipas, nº 135, 4050-600 Porto, Portugal.
Int J Cardiol. 2016 Oct 1;220:501-7. doi: 10.1016/j.ijcard.2016.06.154. Epub 2016 Jun 26.
Growing evidence suggests a possible association between low vitamin D levels and increased cardiovascular risk. However, research regarding the period of adolescence is scarce. We aimed to evaluate the association of vitamin D, intake and serum 25(OH)D levels, with cardiometabolic risk factors in 13-year-old adolescents.
We conducted a cross-sectional analysis of 1033 adolescents evaluated at 13years old as part of the population-based cohort EPITeen. Vitamin D intake was assessed by a food frequency questionnaire. Serum 25(OH)D levels were assessed for a subsample of 514 participants. Metabolic syndrome (MetS) features were defined according to the National Cholesterol Education Program Adult Treatment Panel III definition modified for age. Logistic regression was fitted to estimate the association between vitamin D status and cardiometabolic risk factors, adjusting for sex, parental education, BMI, physical activity and season.
Mean (SD) vitamin D levels, 4.61 (2.50)μg for intake and 16.52 (5.72)ng/mL for serum, were below the recommendations. The prevalence of MetS was 13.2%. Total cholesterol and LDL levels significantly decreased with 25(OH)D serum increase. After adjustment, no association was found between vitamin D levels and MetS. Regarding MetS features, an increased odds of high BMI was observed for those with a lower intake (OR 1.87 95% CI 1.04-3.35).
Although a significant increase in total and LDL cholesterol was observed for lower 25(OH)D levels, and an increased odds of high BMI was observed for those with a lower vitamin D intake, no significant association was observed between vitamin D levels and metabolic syndrome.
越来越多的证据表明维生素D水平低与心血管疾病风险增加之间可能存在关联。然而，关于青春期的研究很少。我们旨在评估13岁青少年中维生素D摄入量和血清25(OH)D水平与心血管代谢危险因素之间的关联。
我们对1033名13岁青少年进行了横断面分析，这些青少年作为基于人群的队列研究EPITeen的一部分接受了评估。通过食物频率问卷评估维生素D摄入量。对514名参与者的子样本评估血清25(OH)D水平。根据针对年龄修改的美国国家胆固醇教育计划成人治疗小组III的定义来定义代谢综合征（MetS）特征。采用逻辑回归来估计维生素D状态与心血管代谢危险因素之间的关联，并对性别、父母教育程度、体重指数、身体活动和季节进行了调整。
维生素D水平的平均值（标准差），摄入量为4.61（2.50）μg，血清为16.52（5.72）ng/mL，均低于推荐值。MetS的患病率为13.2%。随着血清25(OH)D升高，总胆固醇和低密度脂蛋白水平显著降低。调整后，未发现维生素D水平与MetS之间存在关联。关于MetS特征，摄入量较低者高体重指数的几率增加（比值比1.87，95%置信区间1.04 - 3.35）。
尽管25(OH)D水平较低时总胆固醇和低密度脂蛋白胆固醇显著升高，且维生素D摄入量较低者高体重指数的几率增加，但未观察到维生素D水平与代谢综合征之间存在显著关联。
