de Oliveira Marcos Roberto
Department of Chemistry/ICET, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, CEP 78060-900 Cuiaba, MT, Brazil.
Toxicol Lett. 2016 Sep 6;258:185-191. doi: 10.1016/j.toxlet.2016.07.001. Epub 2016 Jul 5.
Fluoxetine (a selective serotonin reuptake inhibitor (SSRI)) is used as an antidepressant by modulating the levels of serotonin in the synaptic cleft. Nevertheless, fluoxetine also induces undesirable effects, such as anxiety, sexual dysfunction, sleep disturbances, and gastrointestinal impairments. Fluoxetine has been viewed as an agent that may interfere with cell fate by triggering apoptosis. On the other hand, fluoxetine intake has been associated with increased cancer risk. Nonetheless, data remain contradictory and no conclusions were taken. Several studies demonstrated that fluoxetine interacts with mitochondria triggering apoptosis and/or altering mitochondrial function by modulating the activity of respiratory chain components and enzymes of the Krebs cycle. Furthermore, fluoxetine affects mitochondria-related redox parameters in different experimental models. In this review, data demonstrating the effects of fluoxetine upon mammalian mitochondria are described and discussed, as well as several unsolved questions in this field of research are addressed. A separate section deals with future needs regarding the research involving the impact of fluoxetine treatment upon mitochondria and mitochondria-related signaling.
氟西汀（一种选择性5-羟色胺再摄取抑制剂（SSRI））通过调节突触间隙中5-羟色胺的水平用作抗抑郁药。然而，氟西汀也会引发不良影响，如焦虑、性功能障碍、睡眠障碍和胃肠道损伤。氟西汀被视为一种可能通过引发细胞凋亡来干扰细胞命运的药物。另一方面，摄入氟西汀与癌症风险增加有关。尽管如此，数据仍然相互矛盾，尚未得出结论。多项研究表明，氟西汀与线粒体相互作用，通过调节呼吸链成分和三羧酸循环酶的活性引发细胞凋亡和/或改变线粒体功能。此外，氟西汀在不同实验模型中影响与线粒体相关的氧化还原参数。在这篇综述中，描述并讨论了证明氟西汀对哺乳动物线粒体影响的数据，以及该研究领域中几个未解决的问题。单独的一节讨论了关于氟西汀治疗对线粒体及与线粒体相关信号传导影响的研究的未来需求。
