Rood J P, Cannell H
Pharmacol Ther Dent. 1978;3(1):45-7.
Volunteer subjects received 50 mg of lignocaine solution as a maxillary infiltration injection, one one occasion as 1% solution and on another as 5% solution. The plasma levels of lignocaine were measured over a two-hour period and similar concentrations were achieved from both solutions, although the larger volumes of the more dilute solution gave slightly higher results, probably reaching toxic levels in one case. The injection of the higher concentration did not produce particularly high plasma levels of lignocaine.
志愿者受试者接受了50毫克利多卡因溶液的上颌浸润注射，一次使用1%溶液，另一次使用5%溶液。在两小时内测量了利多卡因的血浆水平，两种溶液达到了相似的浓度，尽管较稀溶液的体积较大，结果略高，在一个病例中可能达到了中毒水平。注射较高浓度的溶液并没有产生特别高的利多卡因血浆水平。
