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Potential therapeutic value of miR-425-5p in metastatic colorectal cancer.miR-425-5p在转移性结直肠癌中的潜在治疗价值。
J Cell Mol Med. 2016 Nov;20(11):2213-2214. doi: 10.1111/jcmm.12902. Epub 2016 Jul 9.
2
The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer.脱氧胆酸靶向 miRNA 依赖性 CAC1 基因表达调控人结直肠癌细胞多药耐药性
Int J Biochem Cell Biol. 2012 Dec;44(12):2321-32. doi: 10.1016/j.biocel.2012.08.006. Epub 2012 Aug 10.
3
MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10.微小RNA-425-5p通过调控程序性细胞死亡蛋白10来调节结肠癌细胞的化疗耐药性。
J Cell Mol Med. 2016 Feb;20(2):360-9. doi: 10.1111/jcmm.12742. Epub 2015 Dec 9.
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miR-204-5p inhibits proliferation and invasion and enhances chemotherapeutic sensitivity of colorectal cancer cells by downregulating RAB22A.miR-204-5p 通过下调 RAB22A 抑制结直肠癌细胞的增殖和侵袭并增强其化疗敏感性。
Clin Cancer Res. 2014 Dec 1;20(23):6187-99. doi: 10.1158/1078-0432.CCR-14-1030. Epub 2014 Oct 7.
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miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1.微小RNA-139-5p通过靶向NOTCH-1使结肠癌细胞对5-氟尿嘧啶敏感。
Pathol Res Pract. 2016 Jul;212(7):643-9. doi: 10.1016/j.prp.2016.04.011. Epub 2016 May 3.
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miR-139-5p Inhibits the Epithelial-Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2.miR-139-5p通过下调BCL2抑制上皮-间质转化并增强结肠癌细胞的化疗敏感性。
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Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling.通过 miR-195-5p 调控抑制 Notch 信号通路克服结直肠癌细胞干性和化疗耐药性。
Int J Biol Macromol. 2018 Oct 1;117:445-453. doi: 10.1016/j.ijbiomac.2018.05.151. Epub 2018 May 28.
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GDPD5, a target of miR-195-5p, is associated with metastasis and chemoresistance in colorectal cancer.GDPD5 是 miR-195-5p 的靶标，与结直肠癌的转移和化疗耐药有关。
Biomed Pharmacother. 2018 May;101:945-952. doi: 10.1016/j.biopha.2018.03.028. Epub 2018 Mar 22.
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miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma.miR-503-5p通过靶向puma赋予结直肠癌耐药性。
Oncotarget. 2017 Mar 28;8(13):21719-21732. doi: 10.18632/oncotarget.15559.

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1
MicroRNA-425: A Pivotal Regulator Participating in Tumorigenesis of Human Cancers.MicroRNA-425：参与人类癌症发生的关键调节因子。
Mol Biotechnol. 2024 Jul;66(7):1537-1551. doi: 10.1007/s12033-023-00756-5. Epub 2023 Jun 19.
2
miR-4731-5p Enhances Apoptosis and Alleviates Epithelial-Mesenchymal Transition through Targeting RPLP0 in Non-Small-Cell Lung Cancer.miR-4731-5p通过靶向RPLP0增强非小细胞肺癌细胞凋亡并减轻上皮-间质转化
J Oncol. 2022 Mar 17;2022:3793318. doi: 10.1155/2022/3793318. eCollection 2022.
3
Long non-coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR-425-5p expression.长链非编码RNA HCG22通过下调miR-425-5p的表达来抑制口腔鳞状细胞癌细胞的增殖、侵袭和迁移。
Exp Ther Med. 2022 Mar;23(3):246. doi: 10.3892/etm.2022.11171. Epub 2022 Jan 28.
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miRNA-425-5p enhances diffuse large B cell lymphoma growth by targeting PTEN.微小RNA-425-5p通过靶向磷酸酶及张力蛋白同源物（PTEN）促进弥漫性大B细胞淋巴瘤生长。
Transl Cancer Res. 2021 Nov;10(11):4905-4913. doi: 10.21037/tcr-21-2394.
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miRNA-425-5p enhances lung cancer growth via the PTEN/PI3K/AKT signaling axis.miRNA-425-5p 通过 PTEN/PI3K/AKT 信号轴促进肺癌生长。
BMC Pulm Med. 2020 Aug 24;20(1):223. doi: 10.1186/s12890-020-01261-0.
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miR-425-5p suppresses tumorigenesis and DDP resistance in human-prostate cancer by targeting GSK3β and inactivating the Wnt/β-catenin signaling pathway.miR-425-5p 通过靶向 GSK3β 并抑制 Wnt/β-catenin 信号通路抑制人前列腺癌的肿瘤发生和 DDP 耐药性。
J Biosci. 2019 Sep;44(4).
7
Downregulation of microRNA-425-5p suppresses cervical cancer tumorigenesis by targeting AIFM1.微小RNA-425-5p的下调通过靶向AIFM1抑制宫颈癌的肿瘤发生。
Exp Ther Med. 2019 May;17(5):4032-4038. doi: 10.3892/etm.2019.7408. Epub 2019 Mar 18.
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MicroRNA-425 is downregulated in nasopharyngeal carcinoma and regulates tumor cell viability and invasion by targeting hepatoma-derived growth factor.微小RNA-425在鼻咽癌中表达下调，并通过靶向肝癌衍生生长因子调节肿瘤细胞的活力和侵袭。
Oncol Lett. 2018 May;15(5):6345-6351. doi: 10.3892/ol.2018.8128. Epub 2018 Feb 27.
9
SMAD4 feedback regulates the canonical TGF-β signaling pathway to control granulosa cell apoptosis.SMAD4 反馈调节经典 TGF-β 信号通路以控制颗粒细胞凋亡。
Cell Death Dis. 2018 Feb 2;9(2):151. doi: 10.1038/s41419-017-0205-2.
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The suppressive role of miR-542-5p in NSCLC: the evidence from clinical data and in vivo validation using a chick chorioallantoic membrane model.miR-542-5p 在非小细胞肺癌中的抑制作用：来自临床数据和鸡胚尿囊膜模型体内验证的证据。
BMC Cancer. 2017 Sep 19;17(1):655. doi: 10.1186/s12885-017-3646-1.

本文引用的文献

1
MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10.微小RNA-425-5p通过调控程序性细胞死亡蛋白10来调节结肠癌细胞的化疗耐药性。
J Cell Mol Med. 2016 Feb;20(2):360-9. doi: 10.1111/jcmm.12742. Epub 2015 Dec 9.
2
microRNA-425-5p is upregulated in human gastric cancer and contributes to invasion and metastasis and .微小RNA-425-5p在人类胃癌中上调，并促进侵袭和转移。
Exp Ther Med. 2015 May;9(5):1617-1622. doi: 10.3892/etm.2015.2318. Epub 2015 Feb 25.
3
NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction.白细胞介素-1β诱导下，核因子κB依赖性的微小RNA-425上调通过靶向磷脂酰肌醇-3,4,5-三磷酸酶（PTEN）促进胃癌细胞生长。
Mol Cancer. 2014 Feb 26;13:40. doi: 10.1186/1476-4598-13-40.
4
Clinical significance of tumor suppressor PTEN in colorectal carcinoma.肿瘤抑制因子PTEN在结直肠癌中的临床意义
Eur J Surg Oncol. 2011 Feb;37(2):140-7. doi: 10.1016/j.ejso.2010.12.003. Epub 2010 Dec 30.

Potential therapeutic value of miR-425-5p in metastatic colorectal cancer.

作者信息

Cristóbal Ion, Madoz-Gúrpide Juan, Rojo Federico, García-Foncillas Jesús

机构信息

Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Madrid, Spain.

Pathology Department, IIS-Fundacion Jimenez Diaz-UAM, University Hospital "Fundacion Jimenez Diaz", Madrid, Spain.

出版信息

J Cell Mol Med. 2016 Nov;20(11):2213-2214. doi: 10.1111/jcmm.12902. Epub 2016 Jul 9.

DOI:10.1111/jcmm.12902
PMID:27396018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5082410/
Abstract
摘要