胃抑制性多肽：人类基因的结构与染色体定位

Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.

作者信息

Inagaki N, Seino Y, Takeda J, Yano H, Yamada Y, Bell G I, Eddy R L, Fukushima Y, Byers M G, Shows T B

机构信息

Department of Medicine, Kyoto University School of Medicine, Japan.

出版信息

Mol Endocrinol. 1989 Jun;3(6):1014-21. doi: 10.1210/mend-3-6-1014.

DOI:10.1210/mend-3-6-1014

PMID:2739653

Abstract

Gastric inhibitory polypeptide (GIP) is a 42-amino-acid hormone which may have a role in the regulation of insulin secretion. The characterization of cDNA clones encoding this hormone indicates that it is derived by proteolytic processing of a 153-amino-acid precursor. The human gene coding for the human GIP precursor spans approximately 10 kilobase pairs and consists of six exons. Similar to genes encoding other members of the glucagon superfamily, each exon appears to encode a distinct region of the GIP precursor or its mRNA. The promoter region of the human GIP gene contains potential binding sites for a number of transcriptional factors including Sp 1, AP-1, and AP-2. The human GIP gene has been assigned to chromosome 17q21.3----q22.

摘要

胃抑制性多肽（GIP）是一种由42个氨基酸组成的激素，可能在胰岛素分泌调节中发挥作用。编码这种激素的cDNA克隆的特征表明，它是由一个153个氨基酸的前体经蛋白水解加工而来。编码人GIP前体的人类基因跨度约为10千碱基对，由六个外显子组成。与编码胰高血糖素超家族其他成员的基因相似，每个外显子似乎编码GIP前体或其mRNA的一个不同区域。人GIP基因的启动子区域包含多个转录因子的潜在结合位点，包括Sp 1、AP-1和AP-2。人GIP基因已被定位于17号染色体q21.3----q22。