真核生物DNA复制的双环模型。

A double-loop model for the replication of eukaryotic DNA.

作者信息

Spadari S, Montecucco A, Pedrali-Noy G, Ciarrocchi G, Focher F, Hübscher U

机构信息

Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy.

出版信息

Mutat Res. 1989 May;219(3):147-56. doi: 10.1016/0921-8734(89)90009-x.

DOI:10.1016/0921-8734(89)90009-x

PMID:2739671

Abstract

Coordinated DNA synthesis of both strands at the replication fork by a fixed 'replisome' may cause dynamic and topological problems. Based upon known properties of DNA helicase, DNA primase and DNA topoisomerases, and on novel properties of DNA polymerases and DNA ligase, we propose a 'double-loop' model for the replication of eukaryotic DNA that could minimize such problems.

摘要

由固定的“复制体”在复制叉处对两条链进行协调的DNA合成可能会引发动力学和拓扑学问题。基于DNA解旋酶、DNA引发酶和DNA拓扑异构酶的已知特性，以及DNA聚合酶和DNA连接酶的新特性，我们提出了一种真核DNA复制的“双环”模型，该模型可以将此类问题降至最低。