Mei Tian-Sheng, Kou Lei, Ma Sandy, Engle Keary M, Yu Jin-Quan
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037 (USA).
Synthesis (Stuttg). 2012 Jun;44(12):1778-1791. doi: 10.1055/s-0031-1289766. Epub 2012 May 25.
Heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and agrochemicals. Therefore, the design of novel protocols to construct heterocycles more efficiently is a major area of focus in the organic chemistry. In the past several years, cyclization reactions based upon palladium-catalyzed C-H activation have received substantial attention due to their capacity for expediting heterocycle synthesis. This review discusses strategies for heterocycle synthesis palladium-catalyzed C-H bond activation and highlights recent examples from the literature.
杂环化合物广泛存在于天然产物、药物和农用化学品中。因此，设计更高效构建杂环的新方法是有机化学的一个主要研究领域。在过去几年中，基于钯催化C-H活化的环化反应因其能够加速杂环合成而受到广泛关注。本文综述了钯催化C-H键活化用于杂环合成的策略，并重点介绍了文献中的最新实例。
