Onyegbule A O, Onah C C, Iheukwumere B C, Udo J N, Atuegbu C C, Nosakhare N O
Department of Obstetrics and Gynaecology, Federal Medical Centre, Owerri, Nigeria.
Department of Chemical Pathology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.
Niger Med J. 2016 May-Jun;57(3):182-4. doi: 10.4103/0300-1652.184071.
The exact etiology of preeclampsia remains unknown even though several studies have been done. Some studies have shown that supplementation of zinc (Zn) and copper could ameliorate the effects of preeclampsia while other studies did not establish the beneficial role of these elements in preeclampsia. The objective of this study was to compare the Zn and copper levels in the serum of Nigerian women with or without preeclampsia.
In this study, serum Zn and copper levels were determined using atomic absorption spectrometry in 54 patients and 48 healthy normotensive pregnant women. The mean, standard deviation, Student's t-test, and Pearson correlation were employed.
Serum Zn was significantly lower in patients than controls (8.27 ± 0.60 vs. 12.16 ± 1.83 μmol/l. P <0.001) (t-test). Serum copper was also significantly lower in patients than controls (8.14 ± 1.80 vs. 16.62 ± 3.17 μmol/l, P < 0.001).
There was a significant reduction in the levels of Zn and copper in patients with preeclampsia. Dietary supplementation of these trace elements may help to prevent preeclampsia.
尽管已经开展了多项研究，但子痫前期的确切病因仍不清楚。一些研究表明，补充锌（Zn）和铜可以改善子痫前期的影响，而其他研究并未证实这些元素在子痫前期中的有益作用。本研究的目的是比较患有或未患子痫前期的尼日利亚女性血清中的锌和铜水平。
在本研究中，采用原子吸收光谱法测定了54例患者和48例健康血压正常的孕妇血清中的锌和铜水平。采用了均值、标准差、学生t检验和皮尔逊相关性分析。
患者血清锌水平显著低于对照组（8.27±0.60对12.16±1.83μmol/L，P<0.001）（t检验）。患者血清铜水平也显著低于对照组（8.14±1.80对16.62±3.17μmol/L，P<0.001）。
子痫前期患者的锌和铜水平显著降低。膳食补充这些微量元素可能有助于预防子痫前期。
