Nathan I, Hensel R, Dvilansky A, Shainkin-Kestenbaum R
Department of Hematology, Soroka University Hospital, Beer Sheva, Israel.
Nephron. 1989;52(3):251-2. doi: 10.1159/000185651.
Growth of the promyelocytic cell line HL60 and the erythroleukemia cell line K562 is inhibited by 'uremic toxins': creatinine, guanidino propionic acid and guanidino succinic acid in a concentration range similar to that of uremic sera. Among the tested compounds, creatinine exhibits the strongest and most dose-dependent inhibitory effect on both kinds of cells. These results provide a better understanding of the mechanism involved in the anemia of uremic patients.
早幼粒细胞系HL60和红白血病细胞系K562的生长受到“尿毒症毒素”的抑制：肌酐、胍基丙酸和胍基琥珀酸，其浓度范围与尿毒症血清相似。在测试的化合物中，肌酐对这两种细胞表现出最强且最具剂量依赖性的抑制作用。这些结果有助于更好地理解尿毒症患者贫血的发病机制。
