甘草苷对阿尔茨海默病大鼠脑的保护作用
Protective Effects of Liquiritin on the Brain of Rats with Alzheimer's Disease.
作者信息
Huang X, Wang Y, Ren K
机构信息
Department of Pharmacology, Jilin Medical University, Jilin, China. E-mail:
Department of Pharmacology, Jilin Medical University, Jilin, China.
出版信息
West Indian Med J. 2015 Dec;64(5):468-472. doi: 10.7727/wimj.2016.058. Epub 2016 Apr 29.
Abstract
BACKGROUND
Alzheimer's disease (AD) is a sort of nerve degenerative disease with clinical manifestation of memory damage and cognitive dysfunction. Its typical pathological change is the abnormal deposition of amyloid-beta (Aβ).
METHOD
In this study, a rat AD model with liquiritin (LQ) interference was established to observe the effects of LQ on the AD rats' behavioural memory and primary hippocampus cells.
RESULTS
Liquiritin had the effect of improving the rats' learning and memory ability, enhancing the activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in rats' brain tissues, increasing the antioxidant ability, protecting the primary cultured hippocampal neurons and inhibiting the apoptosis induced by Aβ.
CONCLUSION
The protective effects of LQ can be related to the enhancement of antioxidase activity and clearance of oxygen radicals.
摘要
背景
阿尔茨海默病（AD）是一种以记忆损害和认知功能障碍为临床表现的神经退行性疾病。其典型的病理变化是β-淀粉样蛋白（Aβ）的异常沉积。
方法
本研究建立了采用甘草苷（LQ）干预的大鼠AD模型，以观察LQ对AD大鼠行为记忆及原代海马细胞的影响。
结果
甘草苷具有改善大鼠学习记忆能力的作用，可增强大鼠脑组织中过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，提高抗氧化能力，保护原代培养的海马神经元，抑制Aβ诱导的细胞凋亡。
结论
甘草苷的保护作用可能与增强抗氧化酶活性及清除氧自由基有关。
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