Montoya Ryan D
a ECEE Department , University of Colorado Boulder , Boulder , CO , USA.
Electromagn Biol Med. 2017;36(1):102-113. doi: 10.1080/15368378.2016.1194291. Epub 2016 Jul 11.
Some effects of low-intensity magnetic fields on the concentration of radicals and their influence on cellular functions are reviewed. These fields have been implicated as a potential modulator of radical recombination rates. Experimental evidence has revealed a tight coupling between cellular function and radical pair chemistry from signaling pathways to damaging oxidative processes. The effects of externally applied magnetic fields on biological systems have been extensively studied, and the observed effects lack sufficient mechanistic understanding. Radical pair chemistry offers a reasonable explanation for some of the molecular effects of low-intensity magnetic fields, and changes in radical concentrations have been observed to modulate specific cellular functions. Applied external magnetic fields have been shown to induce observable cellular changes such as both inhibiting and accelerating cell growth. These and other mechanisms, such as cell membrane potential modulation, are of great interest in cancer research due to the variations between healthy and deleterious cells. Radical concentrations demonstrate similar variations and are indicative of a possible causal relationship. Radicals, therefore, present a possible mechanism for the modulation of cellular functions such as growth or regression by means of applied external magnetic fields.
本文综述了低强度磁场对自由基浓度的一些影响及其对细胞功能的影响。这些磁场被认为是自由基复合速率的潜在调节剂。实验证据表明，从信号通路到破坏性氧化过程，细胞功能与自由基对化学之间存在紧密耦合。外部施加磁场对生物系统的影响已得到广泛研究，但对观察到的影响缺乏足够的机制理解。自由基对化学为低强度磁场的一些分子效应提供了合理的解释，并且已观察到自由基浓度的变化可调节特定的细胞功能。已表明施加的外部磁场可诱导可观察到的细胞变化，如抑制和加速细胞生长。由于健康细胞和有害细胞之间的差异，这些以及其他机制，如细胞膜电位调节，在癌症研究中具有重要意义。自由基浓度也表现出类似的差异，这表明可能存在因果关系。因此，自由基提出了一种可能的机制，即通过施加外部磁场来调节细胞功能，如生长或衰退。
