白藜芦醇的生物转化：由曲霉属SCSIOW2合成的新型异戊烯基化反式白藜芦醇
Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2.
作者信息
Wang Liyan, Wu Yanhua, Chen Yongtao, Zou Jiaxin, Li Xiaofan
机构信息
Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
出版信息
Molecules. 2016 Jul 6;21(7):883. doi: 10.3390/molecules21070883.
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2. The stereochemistry of 1 was determined by ECD calculations. 1 showed about half of the extracellular radical scavenging effect (IC50 = 161.4 μM) compared with resveratrol (IC50 = 80.5 μM), while on biomembranes it exhibited the same range of protection effects against free radicals generated from AAPH (IC50 = 78.6 μM and 87.9 μM).
Arahypin - 16（1）是一种新的带有独特二氢苯并呋喃环的异戊烯基化白藜芦醇，它是从曲霉属真菌SCSIOW2的全细胞发酵中作为白藜芦醇（2）的微生物代谢产物分离得到的。1的立体化学结构通过电子圆二色（ECD）计算确定。与白藜芦醇（IC50 = 80.5 μM）相比，1表现出约一半的细胞外自由基清除效果（IC50 = 161.4 μM），而在生物膜上，它对2,2'-偶氮二异丁基脒二盐酸盐（AAPH）产生的自由基表现出相同范围的保护作用（IC50 = 78.6 μM和87.9 μM）。
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