Abshire Demetrius A, Moser Debra K, Clasey Jody L, Chung Misook L, Pressler Susan J, Dunbar Sandra B, Heo Seongkum, Lennie Terry A
1 Washington State University College of Nursing, Spokane, WA, USA.
2 University of Kentucky College of Nursing, Lexington, KY, USA.
West J Nurs Res. 2017 Apr;39(4):582-599. doi: 10.1177/0193945916658885. Epub 2016 Jul 11.
The purpose of this study was to examine associations among bone mineral density, osteopenia/osteoporosis, body mass index (BMI), and body composition in patients with heart failure (HF). A total of 119 patients (age = 61 ± 12 years, 65% male) underwent dual-energy X-ray absorptiometry scans to determine bone mineral density and body composition. In multivariable linear regressions, BMI, relative skeletal muscle index (RSMI), and mineral-free lean mass were positively associated with total body bone mineral density. Mineral-free lean mass was most strongly associated with bone mineral density (β = .398). In multivariable logistic regressions, higher BMI, RSMI, and mineral-free lean mass were associated with lower odds for osteopenia/osteoporosis. Fat mass was not associated with total body bone mineral density or osteopenia/osteoporosis. These results suggest that muscle mass may be the important component of body mass associated with bone mineral density in patients with HF.
本研究的目的是探讨心力衰竭（HF）患者的骨矿物质密度、骨质减少/骨质疏松症、体重指数（BMI）和身体成分之间的关联。共有119名患者（年龄 = 61±12岁，65%为男性）接受了双能X线吸收测定扫描，以确定骨矿物质密度和身体成分。在多变量线性回归中，BMI、相对骨骼肌指数（RSMI）和去矿化瘦体重与全身骨矿物质密度呈正相关。去矿化瘦体重与骨矿物质密度的相关性最强（β = 0.398）。在多变量逻辑回归中，较高的BMI、RSMI和去矿化瘦体重与较低的骨质减少/骨质疏松症几率相关。脂肪量与全身骨矿物质密度或骨质减少/骨质疏松症无关。这些结果表明，肌肉量可能是HF患者中与骨矿物质密度相关的体重的重要组成部分。
