Department of Spine, Affiliated Hospital of Zunyi Medical College, Zunyi, People's Republic of China.
Science and Engineering Faculty, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
J Tissue Eng Regen Med. 2017 Oct;11(10):2864-2875. doi: 10.1002/term.2190. Epub 2016 Jul 12.
Blood clots (haematomas) that form immediately following a bone fracture have been shown to be vital for the subsequent healing process. During the clotting process, a number of factors can influence the fibrin clot structure, such as fibrin polymerization, growth factor binding, cellular infiltration (including platelet retraction), protein concentrations and cytokines. The modulation of the fibrin clot structure within the fracture site has important clinical implications and could result in the development of multifunctional scaffolds that mimic the natural structure of a haematoma. Artificial haematoma structures such as these can be created from the patient's own blood and can therefore act as an ideal bone defect filling material for potential clinical application to accelerate bone regeneration. Copyright © 2016 John Wiley & Sons, Ltd.
骨折后立即形成的血栓（血肿）已被证明对随后的愈合过程至关重要。在凝血过程中，许多因素会影响纤维蛋白凝块结构，如纤维蛋白聚合、生长因子结合、细胞浸润（包括血小板回缩）、蛋白质浓度和细胞因子。骨折部位纤维蛋白凝块结构的调节具有重要的临床意义，并可能导致多功能支架的发展，这些支架模拟血肿的天然结构。这种人工血肿结构可以从患者自身的血液中创建，因此可以作为理想的骨缺损填充材料，用于潜在的临床应用，以加速骨再生。版权所有© 2016 年 John Wiley & Sons, Ltd.
