Laboratory of Neurovirology and Inflammation Biology, CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India.
Laboratory of Human Molecular Virology and Immunology, Molecular Biology Unit, Faculty of Medicine, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, India.
Rev Med Virol. 2016 Sep;26(5):356-68. doi: 10.1002/rmv.1893. Epub 2016 Jul 12.
The advances in RNA sequencing have unveiled various non-coding RNAs (ncRNAs), which modulate the gene expression. ncRNAs do not get translated into proteins. These include transfer RNAs, ribosomal RNAs, microRNA (miRNA), short interfering RNA, long non-coding RNA, piwi-interacting RNA and small nuclear RNA. ncRNAs regulate gene expression at various levels and control cellular machinery. miRNAs have been reported in plants, animals, several invertebrates and viruses. The miRNAs regulate the gene expression post-transcriptionally. Viral infection strongly influences the abundance and the distribution of miRNAs and other ncRNAs within the host cells. Viruses may encode their own miRNA, which help in the viral life cycle and other aspects of pathogenesis. Viruses are known to successfully modulate the expression pattern of ncRNAs. The ncRNA-based strategies adopted by viruses for their survival present a complex picture of host-virus interactions. Copyright © 2016 John Wiley & Sons, Ltd.
RNA 测序技术的进步揭示了各种非编码 RNA（ncRNA），它们调节基因表达。ncRNA 不会被翻译成蛋白质。这些包括转移 RNA、核糖体 RNA、微小 RNA（miRNA）、短干扰 RNA、长非编码 RNA、piwi 相互作用 RNA 和小核 RNA。ncRNA 在多个层面上调节基因表达并控制细胞机制。miRNA 已在植物、动物、几种无脊椎动物和病毒中报道。miRNA 在后转录水平上调节基因表达。病毒感染强烈影响宿主细胞内 miRNA 和其他 ncRNA 的丰度和分布。病毒可能编码自己的 miRNA，这有助于病毒的生命周期和发病机制的其他方面。病毒被认为能够成功地调节 ncRNA 的表达模式。病毒为了生存而采用的基于 ncRNA 的策略呈现出宿主-病毒相互作用的复杂图景。版权所有 © 2016 年 John Wiley & Sons, Ltd.
