van der Heide Verena, Homann Dirk
Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eur J Immunol. 2016 Jul;46(7):1587-91. doi: 10.1002/eji.201646500.
Rapid activation and proliferative expansion of specific CD8(+) memory T (CD8(+) TM ) cells upon antigen re-encounter is a critical component of the adaptive immune response that confers enhanced immune protection. In this context, however, the requirements for costimulation in general, and CD28 signaling in particular, remain incompletely defined. In the current issue of the European Journal of Immunology, Fröhlich et al. [Eur. J. Immunol. 2016. 46: 1644-1655] provide definitive evidence that optimal elaboration of CD8(+) TM -cell recall responses is indeed contingent on CD28 expressed by these cells. Here, we discuss the "CD28 costimulation paradigm" in its historical context and highlight some of the unresolved complexities pertaining to CD28-dependent interactions that shape CD8(+) T-cell phenotypes, functionalities, and recall reactivity.
抗原再次接触时，特定CD8(+)记忆T细胞（CD8(+) TM）的快速激活和增殖性扩增是适应性免疫反应的关键组成部分，可提供增强的免疫保护。然而，在这种情况下，共刺激的总体要求，特别是CD28信号传导的要求，仍未完全明确。在本期《欧洲免疫学杂志》中，弗罗利希等人[《欧洲免疫学杂志》2016年。46: 1644 - 1655]提供了确凿的证据，表明CD8(+) TM细胞回忆反应的最佳发挥确实取决于这些细胞表达的CD28。在这里，我们在其历史背景下讨论“CD28共刺激范式”，并强调与塑造CD8(+) T细胞表型、功能和回忆反应性的CD28依赖性相互作用相关的一些未解决的复杂性。
