Department of Pharmacy, Froedtert & The Medical College of Wisconsin, Milwaukee, WI, USA.
Division of Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Mycoses. 2016 Dec;59(12):746-750. doi: 10.1111/myc.12525. Epub 2016 Jul 12.
The fungi Paecilomyces variotii is a potential pathogen in immunocompromised and immunocompetent patients. Their rare association with clinical disease results in scarce literature regarding susceptibility and treatment. Here, we discuss a case involving successful treatment of probable P. variotii pneumonia with posaconazole after treatment failure with voriconazole. The current literature related to antifungal susceptibility profiles, microbiological identification methods and clinical management of infections caused by this organism is also reviewed.
棘白菌素变种被认为是一种潜在的病原体，它可以感染免疫功能低下和免疫功能正常的患者。由于棘白菌素变种与临床疾病的罕见关联，导致有关其易感性和治疗的文献很少。在这里，我们讨论了一例因伏立康唑治疗失败后，使用泊沙康唑成功治疗可能的棘白菌素变种肺炎的病例。还回顾了与该生物体引起的真菌感染的抗真菌药敏谱、微生物鉴定方法和临床管理相关的当前文献。
