Maksimova O V, Solun M N
Probl Endokrinol (Mosk). 1989 Mar-Apr;35(2):14-8.
A total of 50 patients aged 17 to 39 with insulin-dependent diabetes mellitus (DM) were investigated. The following changes in the level and composition of erythrocytic membrane and plasma lipids were detected: an increase in the level of erythrocytes (ER) of total lipids (TL), disorder of the composition of neutral lipids (an increase in the level of total cholesterol--TC and a decrease in the amount of free fatty acids), and a decrease in the level of total phospholipids (PL). The amount of plasma TL, TC and PL was increased. These changes were most noticeable at the stage of carbohydrate metabolic decompensation with disease duration of 5 yrs and were accompanied by a rise of the TC/PL index. According to the literature data the above changes in the erythrocytic membrane lipid composition lead to an increase in ER microviscosity and a decrease in ER deformability, being one of the mechanisms of the development of microangiopathies in DM.
共对50名年龄在17至39岁之间的胰岛素依赖型糖尿病（DM）患者进行了调查。检测到红细胞膜和血浆脂质水平及组成有以下变化：红细胞（ER）总脂质（TL）水平升高、中性脂质组成紊乱（总胆固醇——TC水平升高，游离脂肪酸量减少）以及总磷脂（PL）水平降低。血浆TL、TC和PL量增加。这些变化在疾病病程达5年的碳水化合物代谢失代偿阶段最为明显，并伴有TC/PL指数升高。根据文献数据，红细胞膜脂质组成的上述变化会导致ER微粘度增加和ER变形性降低，这是DM微血管病变发生机制之一。
