Garnier M, Attali J R, Valensi P, Delatour-Hanss E, Gaudey F, Koutsouris D
Groupe d'Etudes et de Recherche en Biorhéologie, Université Paris Nord, Bobigny, France.
Metabolism. 1990 Aug;39(8):794-8. doi: 10.1016/0026-0495(90)90121-r.
Erythrocyte deformability was assessed in 40 diabetic patients, 24 insulin-dependent (IDD) and 16 non-insulin-dependent (NIDD), by measuring the initial filtration flow rate of whole blood, isolated red blood cells (RBC), and isolated RBC membranes with the Hanss hemorheometer, and its relationship to the plasma and ghost membrane lipid composition was investigated. RBC deformability was significantly reduced, whereas the deformability of the isolated RBC membranes did not differ significantly from the controls. In the plasma, the triglycerides were high, the high-density lipoprotein (HDL) cholesterol was reduced, and the ratio of total cholesterol over HDL cholesterol was high as compared with the controls. The RBC lipid composition expressed in mumol lipids/10(10) RBC showed significantly lower levels of free cholesterol, sphingomyelines, and phosphatidylcholine, which are the lipids principally located on the outer layer of the RBC membranes. These data suggest that in both IDD and NIDD patients, there may be a relation between these modifications in the RBC lipid composition and rheological impairment of the RBC.
通过使用汉斯血液流变仪测量全血、分离的红细胞（RBC）和分离的RBC膜的初始滤过流速，对40例糖尿病患者（24例胰岛素依赖型（IDD）和16例非胰岛素依赖型（NIDD））的红细胞变形性进行了评估，并研究了其与血浆和空壳膜脂质组成的关系。红细胞变形性显著降低，而分离的RBC膜的变形性与对照组无显著差异。与对照组相比，血浆中的甘油三酯含量高，高密度脂蛋白（HDL）胆固醇降低，总胆固醇与HDL胆固醇的比值高。以μmol脂质/10(10)个RBC表示的RBC脂质组成显示，游离胆固醇、鞘磷脂和磷脂酰胆碱水平显著降低，这些脂质主要位于RBC膜的外层。这些数据表明，在IDD和NIDD患者中，RBC脂质组成的这些改变与RBC的流变学损伤之间可能存在关联。
