Ageeva T S, Zakharova N B, Rassomakhin A A
Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(1):6-8.
68 patients with cerebrovascular disorders (37 cases of ischemic stroke and 31 cases of dyscirculatory encephalopathy) were examined for microhemorheology (erythrocytic form and deformability); fractional composition of neutral lipids; blood phospholipids; those in red cells and their membrane environment (ME); erythrocytic sorption capacity in plasma and ME by fibrinogen. Neutral lipids were found to undergo metabolic disorders manifested as lowered amount of phospholipids, elevated levels of free fatty acids, triglycerides and cholesterol ethers. The fractional composition shifted to a growing toxic fraction of lysophosphatides and reducing fraction of phosphatydilcholine. The changes were of the same type in all the tested media and seemed interrelated. Along with alterations in the membrane lipid composition there appeared functional changes in erythrocytes: deformability decreased, echinocytes emerged, membrane sorption capacity enhanced, ME fibrinogen rose.
对68例脑血管疾病患者（37例缺血性中风和31例循环障碍性脑病）进行了微血液流变学检查（红细胞形态和变形性）；中性脂质的分数组成；血液磷脂；红细胞及其膜环境（ME）中的磷脂；红细胞对血浆和ME中纤维蛋白原的吸附能力。发现中性脂质发生代谢紊乱，表现为磷脂含量降低、游离脂肪酸、甘油三酯和胆固醇醚水平升高。分数组成向溶血磷脂的毒性分数增加和磷脂酰胆碱分数减少的方向转变。所有测试介质中的变化类型相同，似乎相互关联。随着膜脂质组成的改变，红细胞出现功能变化：变形性降低，棘红细胞出现，膜吸附能力增强，ME纤维蛋白原升高。
