Mirsaeidi Mehdi, Mortaz Esmaeil, Omar Hesham R, Camporesi Enrico M, Sweiss Nadera
Division of Pulmonary, Critical Care, Sleep and Allergy, Department of Medicine, University of Miami, FL, USA.
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Tanaffos. 2016;15(1):44-7.
The neutrophil-to-lymphocyte ratio (NLR) has emerged as a new marker of inflammation associated with the severity of several respiratory and cardiac diseases.
We investigated whether the degree of systemic inflammation in sarcoidosis patients as measured by the NLR is associated with pulmonary hypertension (PH).
A NLR > 3.5 occurred with a significantly higher frequency in sarcoidosis patients with PH (50% vs. 24%, P=0.016) yielding a sensitivity of 50%, specificity of 78%, positive predictive value (PPV) of 41.9% and negative predictive value (NPV) of 81.4% and remained independently associated with PH in multivariate analysis (OR: 3.254, 95% CI: 1.094-9.678, P=0.034).
We conclude that level of inflammation in sarcoidosis patients may be associated with the development of PH. Owing to the relatively good specificity and NPV, NLR may be a good negative test, which is a simple, inexpensive and widely available in office-based setting to predict the risk of PH in sarcoidosis patients.
中性粒细胞与淋巴细胞比值（NLR）已成为一种与多种呼吸道和心脏疾病严重程度相关的新型炎症标志物。
我们研究了通过NLR测量的结节病患者全身炎症程度是否与肺动脉高压（PH）相关。
PH结节病患者中NLR>3.5的发生率显著更高（50%对24%，P=0.016），敏感性为50%，特异性为78%，阳性预测值（PPV）为41.9%，阴性预测值（NPV）为81.4%，在多变量分析中仍与PH独立相关（OR：3.254，95%CI：1.094 - 9.678，P=0.034）。
我们得出结论，结节病患者的炎症水平可能与PH的发生有关。由于相对较好的特异性和NPV，NLR可能是一种良好的阴性检测指标，它简单、廉价且在门诊环境中广泛可用，可用于预测结节病患者发生PH的风险。
