2012年伊朗东部比尔詹德小学生血脂异常患病率

Prevalence of Dyslipidemia among Elementary School Children in Birjand, East of Iran, 2012.

作者信息

Taheri Fatemeh, Kazemi Toba, Bijari Bita, Namakin Kokab, Zardast Mahmoud, Chahkandi Tayyebeh

机构信息

Birjand Atherosclerosis and Coronary Artery Research Center, Birjand University of Medical Sciences, Birjand, Iran.

出版信息

J Tehran Heart Cent. 2016 Jan 13;11(1):15-20.

PMID:27403185

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4939251/

Abstract

BACKGROUND

Various studies have indicated that dyslipidemia starts in childhood. There is a relationship between the concentration of blood lipids and atherosclerosis. In this study, we assessed the prevalence of dyslipidemia in elementary school children.

METHODS

This cross-sectional study was performed on 1,626 (882 girls and 744 boys) elementary school children aged between 6 and 11 years in Birjand in 2012. Samples were selected through multistage random sampling. The lipid profiles (i.e., cholesterol, triglyceride, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C]) of the subjects were measured after 12 hours' fasting. The definition of dyslipidemia was based on the criteria of The American Children Academia in 2011.

RESULTS

Dyslipidemia (at least one abnormal level of a serum lipid) was detected in 31% of the children (31.3% of the girls vs. 30.6% of the boys). Total cholesterol was ≥ 200 mg/dL in 13.4% of the children, LDL-C was ≥ 130 mg/dL in 8.5%, HDL-C was < 40 mg/dL in 11.3%, and triglyceride was ≥ 130 mg/dL in 15.3%. The prevalence of hypertriglyceridemia was significantly higher in the females than in the males (16.3% in the girls vs. 13.8% in the boys; p value = 0.01) - while hypercholesterolemia (12.2% in the girls vs. 14.9% in the boys; p value = 0.16), high LDL-C (8.5% in the girls vs. 8.5% in the boys; p value = 0.05), and low HDL-C (12.7% in the girls vs. 9.5% in the boys; p value = 0.1) were not significantly different between the two sexes.

CONCLUSION

The prevalence of dyslipidemia was high in the school children in Birjand and, thus, requires preventive measures.

摘要

背景

多项研究表明血脂异常始于儿童期。血脂浓度与动脉粥样硬化之间存在关联。在本研究中，我们评估了小学生血脂异常的患病率。

方法

2012年，对比尔詹德1626名（882名女孩和744名男孩）6至11岁的小学生进行了这项横断面研究。样本通过多阶段随机抽样选取。受试者在禁食12小时后测量血脂谱（即胆固醇、甘油三酯、高密度脂蛋白胆固醇[HDL-C]、低密度脂蛋白胆固醇[LDL-C]）。血脂异常的定义基于2011年美国儿科学会的标准。

结果

31%的儿童检测出血脂异常（至少一项血清脂质水平异常）（女孩为31.3%，男孩为30.6%）。13.4%的儿童总胆固醇≥200mg/dL，8.5%的儿童低密度脂蛋白胆固醇≥130mg/dL，11.3%的儿童高密度脂蛋白胆固醇<40mg/dL，15.3%的儿童甘油三酯≥130mg/dL。女性高甘油三酯血症的患病率显著高于男性（女孩为16.3%，男孩为13.8%；p值=0.01），而高胆固醇血症（女孩为12.2%，男孩为14.9%；p值=0.16）、高LDL-C（女孩为8.5%，男孩为8.5%；p值=0.05）和低HDL-C（女孩为12.7%，男孩为9.5%；p值=0.1）在两性之间无显著差异。