Fesharakinia Azita, Zarban Asghar, Sharifzadeh Gholam-Reza
Department of Pediatric Nephrology, Vali-e-Asr Hospital, Birjand University of Medical Sciences, Birjand, Iran.
Arch Iran Med. 2008 Nov;11(6):598-601.
The aim of this study was to evaluate serum lipid profiles and the prevalence of dyslipidemia in schoolchildren in south Khorasan Province.
The participants of this cross-sectional study were 685 girls and 641 boys, aged seven to 12 years, selected by multistage random cluster sampling from urban and rural areas of south Khorasan Province (eastern Iran). Fasting blood samples were analyzed for total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol.
The mean values of total cholesterol and low-density lipoprotein cholesterol were significantly higher in girls. There was no significant correlation between the mean values of serum lipids with age of the children. The mean values of triglyceride and high-density lipoprotein cholesterol were significantly higher and lower, respectively, in rural areas. In all the participants, the percentiles of triglycerides were higher and the percentiles of high-density lipoprotein cholesterol were lower than standard values according to Lipid Research Clinics data. The most common form of dyslipidemia was decreased high-density lipoprotein cholesterol (14.1%). The prevalence of hypertriglyceridemia, increased low-density lipoprotein cholesterol, and hypercholesterolemia were 5.4%, 4.1%, and 3%, respectively. There was not any significant relation between different forms of dyslipidemia with age of the children. Decreased high-density lipoprotein cholesterol and increased low-density lipoprotein cholesterol were significantly more common in girls. The prevalence of decreased high-density lipoprotein cholesterol was significantly higher in rural than urban areas.
Considering the high prevalence of dyslipidemia and undesirable lipid profiles in the schoolchildren of eastern regions of Iran, it is strongly recommended to search for underlying factors.
本研究旨在评估霍拉桑省南部学龄儿童的血脂谱及血脂异常患病率。
本横断面研究的参与者为685名女孩和641名男孩，年龄在7至12岁之间，通过多阶段随机整群抽样从伊朗东部霍拉桑省南部的城乡地区选取。对空腹血样进行总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高密度脂蛋白胆固醇分析。
女孩的总胆固醇和低密度脂蛋白胆固醇平均值显著更高。血脂平均值与儿童年龄之间无显著相关性。农村地区甘油三酯平均值显著更高，高密度脂蛋白胆固醇平均值显著更低。根据脂质研究临床数据，所有参与者的甘油三酯百分位数高于标准值，高密度脂蛋白胆固醇百分位数低于标准值。最常见的血脂异常形式是高密度脂蛋白胆固醇降低（14.1%）。高甘油三酯血症、低密度脂蛋白胆固醇升高和高胆固醇血症的患病率分别为5.4%、4.1%和3%。不同形式的血脂异常与儿童年龄之间无显著关系。高密度脂蛋白胆固醇降低和低密度脂蛋白胆固醇升高在女孩中显著更常见。农村地区高密度脂蛋白胆固醇降低的患病率显著高于城市地区。
鉴于伊朗东部地区学龄儿童血脂异常患病率高且血脂谱不理想，强烈建议寻找潜在因素。
