Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Arch Iran Med. 2013 Mar;16(3):149-53.
To investigate the association between obesity indices, abdominal fat distribution, and lipid profile in patients with stable angina (SA).
Body weight, height, waist circumference (WC), body mass index (BMI), and waist /height ratio (WHtR) of 123 patients with SA who underwent coronary angiography were measured. Fasting blood samples were taken to measure the levels of fasting blood sugar (FBS), total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), apolipoproteins A and B (apo A and apo B), and triglycerides (TG). According to angiography reports, the participants were divided into patients with or without coronary heart disease (CHD). All patients underwent an abdominal computerized tomography (CT) scan to measure the visceral, superficial, and deep subcutaneous fat.
The mean ages of the patients with CHD (n = 73) and without CHD (n = 50) were 50.5 ± 7.6 and 53.7 ± 7.6 years, respectively (P = 0.03). The patients with CHD had significantly higher levels of TC, TG, and superficial subcutaneous fat, while the patients without CHD had higher levels of apo A (P ≤ 0.05). Multivariate analyses showed a significant association of visceral fat with TC, LDL-C, TG, and apo B, in the patients without CHD, while significant inverse associations were found between WC and HDL-C, WHtR, and apo A as well as visceral fat and LDL-C in the patients with CHD.
Among anthropometrics and imaging indices of obesity, WC and WHtR have shown better association between central obesity with dyslipidemia in the patients with CHD, while CT-measured visceral adipose tissue area was the best correlate of dyslipidemia in the patients without CHD.
探讨稳定型心绞痛（SA）患者肥胖指数、腹部脂肪分布与血脂谱之间的关系。
对 123 例行冠状动脉造影的 SA 患者进行体重、身高、腰围（WC）、体重指数（BMI）和腰高比（WHtR）测量。抽取空腹血样测量空腹血糖（FBS）、总胆固醇（TC）、低密度和高密度脂蛋白胆固醇（LDL-C、HDL-C）、载脂蛋白 A 和 B（apo A 和 apo B）以及甘油三酯（TG）水平。根据血管造影报告，将患者分为冠心病（CHD）患者和无冠心病患者。所有患者均行腹部计算机断层扫描（CT）测量内脏、浅部和深部皮下脂肪。
CHD 组（n=73）和无 CHD 组（n=50）患者的平均年龄分别为 50.5±7.6 岁和 53.7±7.6 岁（P=0.03）。CHD 组患者 TC、TG 和浅部皮下脂肪水平显著升高，而无 CHD 组患者 apo A 水平较高（P≤0.05）。多变量分析显示，无 CHD 患者内脏脂肪与 TC、LDL-C、TG 和 apo B 显著相关，而 CHD 患者 WC 与 HDL-C、WHtR 和 apo A 以及内脏脂肪与 LDL-C 呈显著负相关。
在肥胖的人体测量和影像学指标中，WC 和 WHtR 与 CHD 患者中心性肥胖与血脂异常的相关性较好，而 CT 测量的内脏脂肪组织面积与无 CHD 患者血脂异常的相关性最好。
