Cui Yuliang, Bu Hemei, Ma Xianghua, Zhao Sha, Li Xiaona, Lu Shan
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
J Diabetes Res. 2016;2016:7184123. doi: 10.1155/2016/7184123. Epub 2016 Jun 14.
Objective. The aim of our study was to explore the dependent condition of the relationship between uric acid and blood glucose in type 2 diabetes. Research Design and Methods. We measured the HbA1c, serum uric acid, creatinine, lipids profiles, and so forth of 605 newly diagnosed type 2 diabetes patients, and oral glucose tolerance tests (OGTTs) were performed on each patient. The population was divided into high and low insulin groups. Multiple linear regression analyses were conducted to assess the relationship between uric acid and HbA1c. Results. Serum uric acid and HbA1c levels were low in newly diagnosed type 2 diabetes patients. However, we found no significant relationship between uric acid and HbA1c by regression analysis after adjusting total insulin. The concentration of uric acid was inversely correlated with HbA1c in the high insulin group, regardless of patient sex. However, no associations were found in low insulin group. Conclusions. The negative correlation between uric acid and HbA1c is conditional in newly diagnosed type 2 diabetes patients and is related to hyperinsulinemia. Therefore, uric acid is likely only useful as a biomarker of blood glucose in patients exhibiting hyperinsulinemia.
目的。我们研究的目的是探讨2型糖尿病患者尿酸与血糖之间关系的依存条件。研究设计与方法。我们测量了605例新诊断的2型糖尿病患者的糖化血红蛋白、血清尿酸、肌酐、血脂谱等，并对每位患者进行了口服葡萄糖耐量试验（OGTT）。将研究人群分为高胰岛素组和低胰岛素组。进行多元线性回归分析以评估尿酸与糖化血红蛋白之间的关系。结果。新诊断的2型糖尿病患者血清尿酸和糖化血红蛋白水平较低。然而，在调整总胰岛素后，通过回归分析我们发现尿酸与糖化血红蛋白之间无显著关系。在高胰岛素组中，无论患者性别，尿酸浓度与糖化血红蛋白呈负相关。然而，在低胰岛素组中未发现相关性。结论。在新诊断的2型糖尿病患者中，尿酸与糖化血红蛋白之间的负相关是有条件的，且与高胰岛素血症有关。因此，尿酸可能仅在表现出高胰岛素血症的患者中作为血糖的生物标志物有用。
