Xue Bai, Tan Ji Bin, Ning Feng, Sun Jian Ping, Zhang Ke Yi, Liu Li, Wang Shao Jie, Zhang Dong Feng, Qiao Qing, Pang Zeng Chang
Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao 260071, Shandong, China; Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
School of Public Health, Jilin University, Changchun 130021, Jilin, China; Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Biomed Environ Sci. 2015 Dec;28(12):884-93. doi: 10.3967/bes2015.122.
To determine whether elevated serum uric acid (UA) levels are associated with type 2 diabetes diagnosed using HbA1c levels among Chinese adults.
We conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009. A total of 6894 (39.4% men) subjects aged 35-74 years were included in the data analysis. Newly diagnosed diabetes was defined as HbA1c level of ⋝6.5%, and prediabetes was classified as HbA1c level between 5.7% and 6.4% according to the International Diabetes Federation criteria. Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c (HbA1c) levels.
Subjects with prediabetes had higher UA levels than those with normal glucose tolerance, newly diagnosed diabetes, and known diabetes, with corresponding values of 325.1 (82.5) µmol/L, 310.9 (84.2) µmol/L, 291.3 (81.7) µmol/L, 305.2 (83.6) µmol/L, respectively (P<0.001 for all comparisons). Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using HbA1c levels, and the second quartile of UA levels had a higher odds ratio (OR: 4.088; 95% CI: 2.900-5.765) for HbA1c than the other quartiles after adjusting for age, body mass index, sex, marital status, education, income, alcohol consumption, smoking, and cardiometabolic parameters.
Serum UA is significantly associated with type 2 diabetes diagnosed using HbA1c levels, independent of other cardiometabolic parameters.
确定中国成年人中血清尿酸（UA）水平升高是否与使用糖化血红蛋白（HbA1c）水平诊断的2型糖尿病相关。
2006年和2009年在中国青岛进行了两项基于人群的横断面研究。共有6894名（39.4%为男性）年龄在35 - 74岁的受试者纳入数据分析。根据国际糖尿病联盟标准，新诊断的糖尿病定义为HbA1c水平≥6.5%，糖尿病前期定义为HbA1c水平在5.7%至6.4%之间。采用多因素逻辑回归评估UA与使用糖化血红蛋白A1c（HbA1c）水平定义的2型糖尿病患病率之间的关联。
糖尿病前期受试者的UA水平高于糖耐量正常、新诊断糖尿病和已知糖尿病的受试者，相应值分别为325.1（82.5）µmol/L、310.9（84.2）µmol/L、291.3（81.7）µmol/L、305.2（83.6）µmol/L（所有比较P<0.001）。二元逻辑回归分析表明，UA是使用HbA1c水平诊断的2型糖尿病患病率的一个可能预测因素，在校正年龄、体重指数、性别、婚姻状况、教育程度、收入、饮酒、吸烟和心脏代谢参数后，UA水平的第二个四分位数与HbA1c相比，比其他四分位数具有更高的比值比（OR：4.088；95%CI：2.900 - 5.765）。
血清UA与使用HbA1c水平诊断的2型糖尿病显著相关，独立于其他心脏代谢参数。
