Terranova M L, Laviola G, Alleva E
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Roma, Italy.
Dev Psychobiol. 1993 Dec;26(8):467-81. doi: 10.1002/dev.420260805.
The behavioral repertoire of male and female outbred CD-1 mice was characterized during development (postnatal Days 23-47). To assess the effects of the rearing condition, half of the subjects were individually housed (IC) at weaning (Day 21), while the remaining mice were housed in pairs (PC) of same-sex siblings. The occurrence of 22 behavioral items was scored during nine social encounters, 3 days apart, between pairs of unfamiliar same-sex and same-condition animals. Individually housed mice were much more involved than paired subjects in solitary play and social interactions (affiliative, investigative, and soliciting behaviors), while less interested in nonsocial behaviors (exploration, and escape-oriented or maintenance activities). An over-days increment for elements of social behavior was evident, with a peak of affiliative behavior at 23-32 days of age. For gender differences, in contrast with rat data, a marked female primacy in both social and playful behaviors was found. Overall, these findings clearly indicate that the behavioral repertoire of developing mice during paired encounters is strongly affected by both the sex of the subjects and the housing condition they are experiencing.
在发育过程中（出生后第23 - 47天）对远交群CD - 1雄性和雌性小鼠的行为模式进行了表征。为了评估饲养条件的影响，一半的实验对象在断奶时（第21天）单独饲养（IC），而其余的小鼠则与同性同胞成对饲养（PC）。在9次社交接触中，对22种行为项目的发生情况进行了评分，这些接触在不熟悉的同性且条件相同的动物对之间进行，间隔3天。单独饲养的小鼠在单独玩耍和社交互动（亲和、探究和 soliciting行为）中比成对饲养的实验对象参与度更高，而对非社交行为（探索以及逃避导向或维持活动）的兴趣较低。社交行为元素的日增量很明显，亲和行为在23 - 32日龄时达到峰值。关于性别差异，与大鼠数据相反，在社交和玩耍行为中均发现明显的雌性优势。总体而言，这些发现清楚地表明，在成对接触期间，发育中小鼠的行为模式受到实验对象的性别及其所经历的饲养条件的强烈影响。
