人源环状RNA_103636：重度抑郁症潜在的新型诊断和治疗生物标志物。
hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.
作者信息
Cui Xuelian, Niu Wei, Kong Lingming, He Mingjun, Jiang Kunhong, Chen Shengdong, Zhong Aifang, Li Wanshuai, Lu Jim, Zhang Liyi
机构信息
Department of Health Care, Changzhou Maternal & Child Health Care Hospital Affiliated with Nanjing Medical University, Changzhou, People's Republic of China.
Department of Rehabilitation, No. 102 Hospital of Chinese People's Liberation Army, Changzhou, People's Republic of China.
出版信息
Biomark Med. 2016 Sep;10(9):943-52. doi: 10.2217/bmm-2016-0130. Epub 2016 Jul 12.
AIM
This study aimed to determine whether circular RNA (circRNA) molecules in peripheral blood mononuclear cells (PBMCs) could be used as novel non-invasive biomarkers for major depressive disorder (MDD).
MATERIALS & METHODS: Differentially expressed circRNAs were screened using an Arraystar Human CircRNA Array (which includes 13,617 human circRNAs) and qRT-PCR. Thirty MDD patients were randomly selected to retest the circRNA levels after 4-week and 8-week antidepressant regimens.
RESULTS
Four differentially expressed circRNAs were identified between MDD patients and controls, and only down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients.
CONCLUSION
These results suggest that altered expression of hsa_circRNA_103636 in PBMCs is a potential novel biomarker for the diagnosis and treatment of MDD.
目的
本研究旨在确定外周血单核细胞（PBMCs）中的环状RNA（circRNA）分子是否可作为重度抑郁症（MDD）的新型非侵入性生物标志物。
材料与方法
使用Arraystar人类circRNA阵列（包含13,617个人类circRNA）和qRT-PCR筛选差异表达的circRNA。随机选择30例MDD患者，在进行4周和8周抗抑郁治疗后重新检测circRNA水平。
结果
在MDD患者和对照组之间鉴定出4种差异表达的circRNA，仅下调的hsa_circRNA_103636在MDD患者8周治疗后有显著变化。
结论
这些结果表明，PBMCs中hsa_circRNA_103636表达的改变是MDD诊断和治疗的潜在新型生物标志物。
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